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Selectively, but not exclusively
Transcript of Selectively, but not exclusively
Statisticians say mean things
towards a complex systems model
Selectively, but not exclusively
From simple to complex models
The biomedical narrative of tuberculosis orients people towards a monocausal bacteriological understanding of TB.
A vaccine became available in the 1920s.
Antibiotics to treat TB disease were discovered in the 1940s and 1950s
Towards a multifactorial model
Latent tuberculosis infection
Paul H. Mason
Pidoux wanted to enter nonspecific social and environmental variables into the etiological equation of tuberculosis.
Hermann Pidoux (1802-1882)
Chronic Obstructive Pulmonary Disorder
In the brain sciences...
The most accepted definition for neurodegenerative conditions enumerated a group of diseases united only by the gradually progressive disintegration of part (or systems) of the nervous system.
In the brain sciences...
'degeneration' is a term used only for neurological conditions where a scientific explanation is absent.
Most current neurology textbooks do not include degeneration as a nosological term
The largest book on Neurodegenerative diseases does not define these illnesses
‘degeneration’ has a very loose, imprecise meaning, and mostly refers to conditions we know little about and vague gradual disintegration. When brain scientists uncover the mechanics of a neuronal disease, the term ‘degenerative’ is forgotten and a more specific title is given.
“Degeneracy is the ability of different structures to yield the same output.”
Gerald Maurice Edelman, BioEssays, 2004
degeneracy is a more explanatory concept
Degenerate structure-function mapping is crucial for understanding the nature of brain networks.
Language evolution studies
Gottfried Achenwall 1719-1772
- a term of statecraft first coined in 1749 to refer to systematic methods of summarising, in words, a nation's strength, in terms of its natural, economic, military, and human resources.
- the word entered the English language in 1791 and became used in the branch of mathematics concerned with proability and causal inference in the early 20th Century
Adolphe Quetelet 1796-1874
Using a mathematical methods from astronomy, Quetelet erroneously argued that the distribution of a population's characteristics served as a guide to its ideal value, one obscured by the imperfect variation of individuals.
once denoted a flag raised on a pole as a rallying point, but the "standhard" has become a metaphor for the values that a group hold up and aspire to and against which a person is measured
In the 1840s, a carpentry term for upright and perpendicular, the “norm”, became the root for a constellation of words to refer to the common type or standard.
blindspots and biases
targeted to TB
control of projects
Insufficient TB treatment efforts
Insufficient TB screening efforts
Resistance to being diagnosed with TB
Resistance to diagnose TB
Identify and examine any processes through which TB might be stigmatised
Stigma against TB
Bars and enclosed public spaces
Sites of TB transmission
Experience of illness
Social constructions of ability, identity and stigma
Experiences shaped by medical technologies and corporate interests
What were the social forces that predisposesd certain individuals to be exposed to TB?
Broad consequences of diagnosis?
Illness as practice not as problem?
Examine social interaction to understand how people understand and experience illness.
Examine how people interact with and within the healthcare system.
What was the individual’s response?
What was the social response?
National investment in Health infrastructure.
Health investment priorities.
Neglect of non-TB related health issues
Neglect of TB health issues
Shortage of Medical Professionals.
Competition for Medical Professionals.
Competition between TB clinics and other places of healthcare.
Spread of TB
e.g. Pharmaceutical companies
Control of TB
Successful detection and treatment
Common genes controlled by multiple regulators e.g.
MMPL operons (cell membrane transporters),
Lipases and esterases (lipid metabolism),
PPE proteins (unknown function).
multiple different copies of similar proteins e.g.
annotated succinate dehydrogenases (allows respiration under different conditions)
nicotinamide dinucleotide dehydrogenase (an otherwise useful drug target because no mammalian homologues)
Mason, P.H., Degeling, C., Denholm, J. (In Press) Sociocultural Dimensions of Tuberculosis: An overview of key concepts, International Journal of Tuberculosis and Lung Disease.
Mason, P.H., Roy, A., Spillane, J., Singh, P. (2015) Social, historical and cultural dimensions of tuberculosis, Journal of Biosocial Science.
Mason, P.H. (2015) Degeneracy: Demystifying and destigmatising a core concept in systems biology,
Complexity, 20(3), 12-21.
Mason, P.H., Domínguez, J.F., Winter, B., Grignolio, A. (2015) Hidden in Plain View: Degeneracy in complex systems, BioSystems, 128, 1-8.
Mason, P.H. (2010) Degeneracy at multiple levels of complexity, Biological Theory: Integrating
Development, Evolution and Cognition, 5(3), 277-288.
Maleszka, R., Mason, P.H., and Barron, A.B. (2014) Epigenomics and the concept of degeneracy in biological systems, Briefings in Functional Genomics, 13 (3), 191-202. doi: 10.1093/bfgp/elt050
Park, H., & Friston, K. (2013) Structural and Functional Brain Networks: From Connections to Cognition. Science, 342, 579.
degeneration is passé
Degeneracy is an unfortunate term.
e.g. Johnson, A., 1898. Concerning a form of degeneracy. I. The condition and increase of the feeble-minded. Am. J. Sociol. 4326–4334.
People with tuberculosis were once described as degenerate.
degeneracy & pluripotentiality
Karl Pearson introduced the term "standard deviation", which, together with Quetelet's work, oriented the scientific measurement of populations towards singular values.