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The receptors and cells for mammalian taste

Fisiología
by

Jorge Maldonado

on 6 November 2014

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Transcript of The receptors and cells for mammalian taste

The receptors and cells for mammalian taste
Jayaram Chandrashekar, Mark A. Hoon, Nicholas J. P. Ryba2 & Charles S. Zuker
NATURE|Vol 444|16 November 2006
Amargo
Salado
Dulce
Umami
Ácido
Sweet Taste
GPCRs
Umami taste
Aspartato
Glutamato
Bitter taste
T2Rs
PTC
Salt and sour tastes
Canales de Na+
HCN
ASIc
K2P
K2H+
Na+/H+
PKD2L1
TRC
Toxina
PKD2L1
Co2
Control
homeostático

Mb. Neuronal
Bitter
Sweet
Rassl
Células dulces
Células amargas
Respuesta
Spiradolina
P2x2 - P3x3
Bitter
Sweet
Sour
Salty
Umami
El gusto como instrumento de conocimiento y relación con el medio
Interpretación de los sabores
Anatomía de papilas gustativas
Teorías del gusto
Teorías de percepción y transmisión del sabor
Receptores
Receptor de sabor dulce
Sensibilidad de percepción
Ikukonae Ikeda 1908
Relación de umami y salado
Umami + ribonucleotidos =
Experimento en animales
Receptores
Receptores altamente inespecíficos
Receptores con vías comunes
Receptor TRC
Dependiente de temperatura
Mediación independiente de TRC
para salado y agrio
Percepción de sabores ácidos
Vías alternativas
para el sabor
salado

Experimentos de intercambio de receptores y células
Receptores purinérgicos
Full transcript