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Transcript of Rh Isoimmunization
Ig G can cross placenta.
1st baby usually escape.
Next pregnancy will be affected if ....??
Each pregnant women should know her Rh typing
AntiD immunoglobulin ;
Does? less , optimum , more?!!
1. Antibody screen :
. At 1st antenatal visit.
. Repeated at 28 weeks.
. Indirect coomb's test
. 4 fold increase is significant.
c, C, e, E, G
In Caucasians,15% are Negative.
Weak D, Partial D.
Rh Mod, D(el)
30 days of gestation.
ONLY on red blood cells.
Mother response if exposed to Rh D antigen??
Inadvertent Rh + blood transfusion.
Injection by Rh + blood contaminated needles.
D-mismatched allogenic stem haematobiotic cell transplacentation
Fetomaternal haemorrhage .
Strong response , but may be not ??
when cause of alloimuinization is couldn't be recalled?
The antibody response develops slowly, and is usually not detectable serologically until 5 to 15 weeks after immunization.
Immunogenecity of the fetal RBCs
Immune response of the mother
First affected pregnancy
Repeat test MONTHLY till 24 weeks then every 2 WEEKS
Remains below critical value (16)
Titer above critical value (32)
till 24 weeks
Deliver at term
MCA Doppler / 1-2 weeks
Determine fetal RH type
Free fetal DNA
Peak MCA velocity less than 1.5 MOM
Antenatal testing at 32 weeks
Deliver at 37-38 weeks
MCA PSV more than 1.5 MOM
Fetal HCT more than 30%
Fetal HCT less than 30%
Previously affected pregnancy
No need for titer
At 18 weeks