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Emily Pegel

on 2 March 2015

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Transcript of Lupus

When it affects the
central nervous system
headaches, confusion, fatigue, depression, seizures, strokes, vision problems, mood swings, difficulty concentrating.
When it affects the
peripheral nervous system
vision problems, facial pain, ringing in the ears, dizziness, drooping of an eyelid, carpel tunnel syndrome.
When it affects the
autonomic nervous system
numbness, burning, tingling, mental confusion, headaches, gastrointestinal problems such as nausea, vomiting, constipation or diarrhea.

How does this
affect the whole body?
The immune system is a tightly regulated network that is able to maintain a balance of immune homeostasis under normal physiological conditions. Normally, when challenged with foreign antigen, specific appropriate responses are initiated that are aimed at restoring homeostasis. However under particular circumstances, this balance is not maintained and immune responses either under or over react. Cancer is an example of a situation where the immune response can be inefficient or unresponsive, resulting in uncontrolled growth of the cancer cells. Conversely, when the immune response over-reacts, this can result in conditions such as autoimmunity or pathology following infection. Many drug therapies have been developed that aim to alleviate or prevent such immune disorders and restore immune homeostasis.
What is
happening on the cellular level?
“Lupus is a chronic inflammatory disease that can affect various systems of the body, especially the skin, joints, blood, and kidneys. The body's immune system normally makes proteins called antibodies to protect the body against viruses, bacteria, and other foreign materials. These foreign materials are called antigens. In an autoimmune disorder such as lupus, the immune system loses its ability to tell the difference between foreign substances (antigens) and its own cells and tissues. The immune system then makes antibodies directed against "self." These antibodies, called "auto-antibodies," react with the "self" antigens to form immune complexes. The immune complexes build up in the tissues and can cause inflammation, injury to tissues, and pain.”

What are
the symptoms?
The drug I would
create would be one that
directly effects the cells in a persons body.
Works Cited
"How Does Lupus Affect the Nervous System?" How Does Lupus Affect the Nervous System? Web. 2 Mar. 2015. <http://www.lupus.org/answers/entry/lupus-and-the-nervous-system>.
For the body to return to homeostasis, the cells must first attacking 'self.' Then the body will have a chance to regenerate all of the lost cells and the different parts and systems will start functioning properly again.
What system(s) in
the body does this disease attack?
A solution to the problem
When cells don't communicate: Lupus
It effects many parts of the body like joints, skin, kidneys, heart, lungs, or blood. The systems it most commonly attacks include the central nervous system, the peripheral nervous system, and the autonomic nervous system. To specify; the brain and spinal cord, the network of nerves that connect the brain and spinal cord to the rest of the body, and gives skin and muscles the signals needed for sensation and movement. And also effects the communication between spinal and peripheral nerves and the brain and internal organs, and controls functions like breathing, blood flow, and heart rate.
If I were to address the main issue caused by lupus, I would give patients and anti-inflammatory, and I would also try to come up with some kind of way to help the patients’ cells differentiate between self and non self.
It would contain information that it gives to the attacking cells to basically tell them what not to attack.
"Living With Lupus: In What Ways Can Lupus Affect the Body?" Mollys Fund. 13 Feb. 2013. Web. 2 Mar. 2015. <http://www.mollysfund.org/2013/02/living-with-lupus-in-what-ways-can-lupus-affect-the-body/>.
"Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine. Web. 2 Mar. 2015. <http://www.ncbi.nlm.nih.gov/pubmed/16375694>.
"What Is Lupus, Symptoms, Causes and Treatment." Left Leg First. Web. 2 Mar. 2015. <http://leftlegfirst.com/what-is-lupus/>.
"What Is Lupus?" - Lupus International. Web. 2 Mar. 2015. <http://www.lupusinternational.com/About-Lupus-1-1/What-is-Lupus-.aspx>.
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