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philadelphia translocation

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carlton mukasaclark

on 15 January 2013

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Transcript of philadelphia translocation

Where & How? Also known as Philadelphia Chromosome Philadelphia
Translocation Is there a cure? There is no cure for Philadelphia Translocation. However, the most
common cancer that it causes
(Chronic Myelogenuous Leukemia- CML)
can be treated with bone marrow
transplants and a drug called Gleevec(R).
Because of this drug, the prognosis for Philadelphia pateints
with CML is very good.
How Common? Philadelphia Translocation is the most common genetic translocation. What it causes? Several forms of cancer are caused by Philadelphia Translocation
acute myelogenous leukemia and chronic myelogenous leukemia (CML-most Philadelphia patients acquire this cancer at come point)
Down syndrome is also possible, but is not caused by Philadelphia Translocation Philadelphia Translocation takes place in a
single bone marrow cell. Part of the 9 and 22 chromosomes break of and switch places. This switching is called translocation. The new Chromosome created is called the Philadelphia Chromosome. Facts Philadelphia chromosome was first discovered in
1960 by Peter Nowell from University of Pennsylvania School of Medicine and David Hungerford from the Fox Chase Cancer Center's The discovery of the Philadelphia chromosome helped create a new era of treatment for CML called Tyrosine. 95% of people with Philadelphia Translocation have Chronic Myelogenuous Cancer (CML) By: Carlton Mukasa Clark, Sean Walsh, and Laura Baudoux What is Translocation? Translocation is a chromosome
abnormality caused by the
rearrangement of pieces
of chromosomes 5% of Philadelphia pateints with Philadelphia Translocation also have Down Syndrome Sources http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CML.html
ttp://pubweb.fccc.edu/philadelphiachromosome/history.html
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CML.html

http://bloodjournal.hematologylibrary.org/content/117/25/6793.full

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CML.html

http://www.medterms.com/script/main/art.asp?articlekey=4870

http://www.umm.edu/patiented/articles/what_causes_acute_lymphocytic_
leukemia_000086_3.htm

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CML.html
Full transcript