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TRANSFER OF SYMPTOMATIC PEANUT
Transcript of TRANSFER OF SYMPTOMATIC PEANUT
Two types- helper T cells and killer T cells. Helper T cells create an immune response. Killer T cells scan surface of cells.
T cells can lead to- rejection of transplanted organ, diseases and allergic reactions.
Allergy transfer is known to come from bone marrow transplants.
Donor T cells could have stowed away.
Why liver and not pancreas?
Dendritic cells are experts at presenting antigens to T cells.
Can allergies actually be passed between Donor and recipient?
Research has found that peanut allergies occur in people who’s TH2 Helper cells are activated by the proteins in peanuts, the Allergy is not found in people who produce TH1 helper cells in response to peanut proteins. Babies tend to be born with TH2 biased immune responses which change to TH1 with microbiological exposure and early exposure to allergens.
What causes Peanut Allergies?
* Anaphylaxis IgE production depends on B-cell and T-cell interaction.
* Th2-cells from donor highly deemed among the most likely to be responsible for reaction.
* Could have been created by hematopoietic stem cells in donor’s liver.
* May have stimulated IgE production by host’s cells.
* Possible passage through the lymph system, could account for microchimerism on skin
Inconclusive cell proliferation assay- argues persistance of memory T-cells
How t-cells relate to the case study
2 types of T cells- helper and killer
Allergy transfer- usually from bone marrow transplant.
Dendritic cells possible cause of peanut allergy
Peanut allergies evident in people with TH2 cells- activated by proteins in peanuts.
T-cells relate back to the case study by a cell proliferation assay- returned as inconclusive.
Production of IgE cells also dependent on TH2 cells and B-cells.
Passing of host cells through lymph system- possibly responsible for microchimerism.
Thank you for listening!
Transfer of symptomatic peanut allergy to the recipient of a combined liver-kidney transplant
By Hayleigh Pepper, Ciaran Fogarty, Tracey Tuite, Seaghan Conneely and Jessica Hoey