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Transcript of Bioreactors
- Tissue Engineering
Conclusion Agenda The term is normally used to describe where a biologic reaction takes place.
(De Bry, 1986)
System used to grow large quantities of biochemical cultures to produce enzymes, antibiotics, or blood cells.
(Encarta Encyclopedia, 2000) A very quick review: Landfill Bioreactor Tissue Engineering Thank you! References CHEN 6701 – Advanced Reaction Engineering
Prof. N. R. Foster Bioreactors Not biting around the bush! Bioreactors: Classification Presence of oxygen: i.e. aerobic or anaerobic.
Mode of operation: i.e. Batch, Fed-batch and Continuous bioreactors.
Method of growing microbes: i.e. moving beds, fibrous beds, packed beds or membrane.
Microbial agent: i.e. those using living cells or using enzymes
Process requirements: i.e. solid state or immobilized. Bioreactors: Desirable Properties Simplicity of design
Continuous operations with narrow distribution time
Large number of organisms per unit volume
Uniform distribution of microorganisms
Simple and effective mixing
Low energy requirement
Uniform distribution of energy Landfill Landfill Landfill Landfill Landfill Landfill Landfill Landfill Aerobic Bioreactor Anaerobic Bioreactor Design Considerations:
- Liquid collection
- Impact of liquid on stability
- Integration with final closure
- Geometry of cell
- Integration with LFG collection Operational Considerations:
- Leachate availability
- Leachate recirculation methods
- Degree of automation
- Liquids balance Landfill Bioreactor (2:03-3:40) Landfill Bioreactor http://www.youtube.com/watch?v=--fiEnVKXRA (>1:58) Tissue Engineering Does tissue engineering uses bioreactor? Second artificial trachea implant performed in Sweden, 2011. Spinner Flask:
Is a basic form of a tissue-engineered bioreactor that is ideal for cultures cultivated under static conditions. Perfusion Systems:
The perfusion bioreactor is known for its ability to constantly replenish the cells with media and oxygen to provide a nutrient rich desired environment. Rotating Wall Vessel (RWV):
Is the most commonly used bioreactor that reduces shear stress since the cells are grown in a microgravity environment. Bioreactor product
Lung http://www.youtube.com/watch?v=lfqxbwbjw00&feature=related (<0:18)
Interesting bioreactor conditions.
Tissue Engineering http://www.youtube.com/watch?v=0taE4F0Wkhg&feature=related (>0:23) Artificial Lung: No especial effects!!! Specific Operating Conditions of a Bioreactor Z3294402@student.unsw.edu.au By Antonio Miranda Anand, S (2011), Bioreactors – Classification and Types, Biotech Articles, www.biotecharticles.com, viewed 7/10/2012.
Chen C., Hu Y. Bioreactors for tissue engineering (2006) Biotechnology Letter, 28, pp. 1415-1423.
Klein, B., (2011), First Artificial Trachea Implants Breathe Life into Tissue Engineering, Medgadget online, viewed 7/10/2012 (at http://medgadget.com/2011/12/first-artificial-trachea-implants-breathe-life-into-tissue-engineering.html).
Martin I., Wendt D., Heberer M. The role of bioreactors in tissue engineering (2004) Trends in Biotechnology, 22 (2), pp. 80-86.
Reinhart, D. R. and Townsend, T. G. 1998. Landfill Bioreactor Design and Operation. Lewis Publishers, Boca Raton, Fla.
Richardson, G., (2003), Landfill Bioreactor Design and Operation, US EPA Workshop on Bioreactors, February, USA.
U.S. Environmental Protection Agency, Bioreactors, last update 24th July, 2012, viewed 07/10/2012 (at http://www.epa.gov/osw/nonhaz/municipal/landfill/bioreactors.htm).
Vesilind, P. A., Worrell, W., and Reinhart, D. R. 2002. Solid Waste Engineering. Brooks/Cole, Pacific Grove, Calif.
Yang, S.T. (2010), Bioreactor, Dept. Chemical and Biomolecular Engineering, The Ohio State University, USA.