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Cystic Fibrosis

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Alejandro Martinez

on 22 May 2015

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Transcript of Cystic Fibrosis

Cecilia Madrigal,
Stephanie Ceballos,
Lilian Hernandez,
Alejandro Martinez

What is Cystic Fibrosis?
Who is affected by Cystic Fibrosis?
A hereditary disorder affecting exocrine glands
production of abnormally thick mucus
blockage in the pancreatic ducts, intestines and bronchi
- Hereditary
- 12 million americans are carriers of CF gene.

It is a multi-system disease
Cystic Fibrosis is most commonly found in White people with Northern European ancestry
Some carriers are resistant to some bacteria
Patients eat high calorie foods
Albert Einstien was thought to have suffered from Cystic Fibrosis
Organs Affected
Statistics about cystic fibrosis?
-Lungs: Infection & breathing issues
-Liver and Gallbladder: bile & gallstones
-Pancreas: loss of digestive enzymes
-Small intestine: Not enough nutrients
-Reproductive tract: infertility
-Skin: saltiness
-Most of those affected die between the ages of 20-23
- lifelong hereditary disease
-Average lifespan is around 37 years
- in 90% of cystic fibrosis cases the airways are affected
How Organs are Affected
there is no cure but treatments can reduce complications
antibiotics to treat & prevent lung infections
mucous thinning drugs
Broncho dilators
oral pancreatic enzymes
postural drainage
Risk Factors

Family History- Cystic Fibrosis is an inherited disorder, so it runs in the family
Race- Although it occurs in all races, it most commonly affects people with a Northern European ancestry
1 in 29 Caucasians carry the gene
-Sweat Test
-Genetic Test
-New Born Screening
-Imaging tests
-Lung Function Tests
-Sputum Culture
- Persistent cough with mucus
- Wheezing
- Large, greasy bowel movement
- Difficult to gain weight
- Skin tastes like salt
- Lung congestion
- Gassy
Classes of Cystic Fibrosis
Five Classes:
Class I - (7%) Shortened CFTR (Cystic Fibrosis Trans membrane Conductance Regulator), which helps transport chloride ions to regulate sodium levels
Class II - (85%) Protein fails to reach membrane
Class III - (< 3%) Channels cannot be regulated properly
Class IV - (< 3%) Reduced chloride conductance
Class V - (< 3%) Reduced due to incorrect splicing of gene
How Respiratory System Is affected
Chronic infections
Collapsed lungs
Respiratory failure
Cough up blood
pulmonary hypertension

Fun Facts
thick mucous allows Bacteria to grow and Thrive which causes infection
Full transcript