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Anti-inflammatory, antiallergy and immunosuppressant drugs

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Jennifer Thankachan

on 11 March 2016

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Transcript of Anti-inflammatory, antiallergy and immunosuppressant drugs

The Body's Defenses
innate (skin, phagocytes, etc.)
adaptive (immune response)
antibody-mediated (humoral)
antigen + B cell = ab
cell-mediated
T cells (helper & cytotoxic) secrete cytokines
interferon
interleukin
Treatment of Immune Response Dysfunction

overactive immune response = autoimmune disease

underactive immune response = immunodeficiency/immunocompromised
Immune Response Dysfunction
Hep B Vaccine
Prototype Drug
suppress the immune system's response in order to:
decrease body's ability to attack & reject a transplanted organ
treat autoimmune disorders such as Lupus
Prevention of transplant rejection
Drugs for Immune System Modulation
Jennifer Thankachan, RN, MSN
(too much cortisol)
Adverse Effects of Immunosuppression
risk of infection
prolonged healing time
increased risk for bleeding
N/V; loss of appetite
tremors
increased growth of hair
*many drug interactions possible- thorough medication reconciliation is essential
Immunostimulants: boost a pt's immune system
BRMs
interferons
alpha tx leukemia, AIDS, Hep B&C
beta tx MS, osteoporosis, CGD (PIDD)
interleukins
Prototype Drug
interferon alpha 2b
classified as: BRM & interferon
treats: CA, HPV, Hep B&C
*administered only by trained HCPs
AE: flu-like symptoms
*do not use ETOH w/this drug
Vaccination: a preparation of killed, living-attenuated or living virulent organisms administered to produce or increase immunity to an infectious disease
*more to come on specific vaccination schedules in your Peds course
classified as a vaccine
series of 3 IM injections
*contraindicated in pts allergic to yeast/yeast products
**anaphylactic response possible, have epi on hand when administering first dose
active vs. passive immunity
active: immune system has been stimulated to produce ab

passive: pre-formed ab are transferred from one person to another
organ transplant rejection
acute: humoral (ab-mediated) immune response; pt's antibodies destroy transplanted tissue w/in days
cell-mediated rejection is slower, about 2 weeks
chronic rejection can occur months to years later
immunosuppressants
aka "anti-rejection" drugs
Prototype Drug
prednisone
classified as a corticosteroid and used long-term for anti-rejection
also used for short-term treatment of severe inflammation
AE = potential for
Cushing Syndrome:
weight gain
hyperglycemia
mood changes
HTN
weakness/fatigue
fat deposits in face/shoulders
examples = prednisone,
cyclosporine
Immunosuppressant Drugs
corticosteroids
antimetabolites
calcineurin inhibitors
antibodies
Prototype Drug
cyclosporine
classified as a calcineurin inhibitor
inhibits helper T cells
*administered only by specially trained HCPs
AE: reduction in urine output, HTN, tremor, HA
**monitor renal function
Nursing Considerations
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