Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Green Chemistry

Green chemical processes in the pharmaceutical industry
by

Melani Fernando

on 8 April 2013

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Green Chemistry

http://photosof.org/walls/small_waterfall_in_river_surrounded_by_green_trees-normal.jpg GREEN PROCESS CHEMISTRY
IN THE
PHARMACEUTICAL INDUSTRY T. Melani M. Fernando 9839 http://blog.saintandsmith.com/wp-content/uploads/2011/09/antibiotics.jpg OVERVIEW Background & introduction to green chemistry Application of green principles in the pharmaceutical industry and its current trends Global focus and future planning "hurt not the earth, neither the sea,
nor the trees."
-Ronald C. D. Breslow. http://www.epa.gov/sciencematters/june2011/images/steps.jpg ".....The utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and applicaton of chemical products." http://www.newscientist.com/data/images/ns/cms/mg20527511.500/mg20527511.500-1_500.jpg How did green technology come in to picture and why is it important? http://www.baraka.lk/wp-content/uploads/2012/02/control-pollution-and-save-planet-21304647.jpg Two main branches;
Green Chemistry and Green Engineering The 12 Principles of Green Chemistry Prevention Atom Economy Less hazardous chemical
synthesis Designing safer chemicals Safer slovents and auxiliaries Design for energy efficiency Use of renewable feedstock Reduce derivatives Catalysis Design for degradation Real-time analysis for pollution
prevention Inherently safer chemistry for
accident prevention http://www.greenchemistrynetwork.org/pdf/Principles.pdf http://www.greenchemistrynetwork.org/pdf/Principles.pdf http://www.greenchemistrynetwork.org/pdf/Waste.pdf Figure 1 Figure 2 Table 1: Comparison of chemical industry sectors by quantity of byproduct per kilogram of product http://www.clearclinic.com/wp-content/uploads/2013/03/antibiotics-for-acne-best-acne-treatment.jpg GlaxoSmitKline (GSK): A life Cycle study of waste produced from their Active Pharmaceutical Ingredient (API) 80% Solvent related waste Old route Greener route Table 2: Class II solvents and their limits in pharmaceutical products Table 3: Solvent replacement table Figure 3: Synthetic route
of Sildenafil citrate Old route Greener route Figure 4: Synthetic route of Setraline I Figure 5: Sythetic route of Setraline II Figure 6: Synthetic route of Sitagliptin Figure 7: Solvent use comparison in original and new
processes of Quinapril synthesis Figure 8: Solvent usage and waste generation comparisons
of old/new processes of Celecoxib synthesis Greenest Solvent : Water Others:
Supercritical carbon dioxide
and
ionic liquids http://www.navigantresearch.com/wordpress/wp-content/uploads/2011/06/Green-Chemistry1.jpg Further Applications Use of renewable feedstock in
gold nanoparticle synthesis Reusable Zeolite catalysts:
Regioselectivity in nitration,
halogenation etc.. of simple
aromatics American Chemical Society (ACS)
Green Chemistry
Institute (GCI) AstraZeneca Eli Lilly & Company GlaxoSmithKline Pfizer Johnson & Johnson Merck & Company Schering-Plough Corporation Table 4: Reactions companies use now, but would strongly prefer better reagents Eco Friendly Pharmaceutical
Packaging Material Cellulose Corn Starch Xylan Chitin/Chitosan Protein Green Metrics Trost's atom economy (AE) Sheldon's Environmental
Impact factor (E) Reaction Mass Efficiency (RME) a,b,p,q= Molecular weight x,y= no. of moles w=Mass of unreacted reactants Other Issues... http://www.dispatch.com/content/graphics/2012/11/13/antibiotics.jpg 92% of US hospitals and nursing homes
throw away 250 million pounds of pills
and drug contaminated packaging every
year!
85-90% of pharmaceutical and personal
care product contamination in
water is caused by individuals http://tcs2009batch.webs.com/Business_hands_together%20(1).jpg Effort of a multi-disciplinary team http://www.epa.gov/greenchemistry/index.html http://fusion.stolaf.edu/gca/ http://www.greenchemistrynetwork.org/ http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_TRANSITIONMAIN&node_id=830&use_sec=false&sec_url_var=region1&__uuid=b0bb9fbf-7c2b-4875-9407-8853002de0cf http://www.greenchemistrynetwork.org/pdf/Principles.pdf References Thank You!! Go Green!!! Q & A References
Full transcript