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ATP , LIFE'S ENERGY CURRENCY

ATP has a crucial role to play in making energy available for metabolic reactions in living organism
by

Woon Lainam

on 20 January 2013

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Transcript of ATP , LIFE'S ENERGY CURRENCY

sustain life Use of ATP in Metabolic Pathways A T P Molecule of Adenosine Tri Phosphate Life's energy currency The nucleotide , ATP has a crucial role play in making energy available for metabolic reaction short term energy source for cellular activity is synthesis in mitochondria ATP Molecule of ATP There are o- at the top of triphosphate

o- like each other and try to move apart
repulsion force strong enough to stress on bond
so e- shared in those bond and create excited region
(ATP energy excited state ) OH- H+ - The OH- attracted to phosphorus H+

attracted to O- bond between 2 phosphate is break down O H H Structure... ATP broken into 3 molecules :
Adenin ~ same molecules found in DNA
Ribose ~ same molecules found in RNA
Triphosphate ~ 3 phosphate group linked in a short chain Breakdown of ATP = exothermic rxn
The released E used by enzymes to power the catalyst rxns
ATP + H2O ADP +Pi Hydrolysis ΔG˚ = 30.5 kJ/mol (covalently bonded to hydroxyl gp of sugar) adenosine + H2O adenosine OH + H + + Triphosphate diphosphate The hydrolysis of ATP in the cell releases a large amount of free energy. Hydrolysis it's function form complex sequence of rxns that linked in pathways sequence of rxn make up the metabolism of the cell each rxns pathway catalysed by enzymes ADP + Pi ATP +H2O Phospholyration Hydrolysis energetically unfavourable energetically favourable linked to food + oxygen oxidised products
CO2 +H2O oxidation of food energetically favourable linked to Chemical Synthesis
Transport of ions across membrane
Movement of electric charge in nerve cells
Muscle Contractions
Catabolic & Anabolic Reaction Uses of ATP Metabolic pathways
use large amounts of ATP
ATP-dependent process produces ADP
hence Metabolism is the regeneration of ATP
Reaction = energetically endothermic
Oxidation of food = Energy generates~ GLYCOLYSIS lysis Kreb CYCLE + link reaction Oxidative Phospholyration Overall ATP generation Glycolysis - 2 ATP
- 2 NADH (= 6 ATP)

Link reaction - 2 NADH (=6 ATP)

Krebs Cycle - 6 NADH (= 18 ATP)
- 2 FADH (=4 ATP)
- 2 ATP

OVERALL : 38 mol ofATP

(oxidation 1 glucose = 38ATP ) ATP Generation Generation of ATP the splitting of water molecules bond broken down =excited e- can now relax
as relax = release energy
that energy released power everythings in cell and living world Although it's really a bit of energy, but if multiply thousand times, there are enough energy to run a cell~ Conclusion The step in this metabolic pathways tend to required relatively small ,manageable amounts of energy which need to be readily accessible to continously "drive"the activities of cell P hosphate R ibose A denin adenosine + H2O adenosine OH + H + + Triphosphate diphosphate The hydrolysis of ATP in the cell releases a large amount of free energy. Hydrolysis
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