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Grant Proposal

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by

Alexia Skiadas

on 10 December 2014

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Transcript of Grant Proposal

Grant Proposal:
Stem Cell Research of Baby and Wisdom Teeth
Matthew Hasley
George Stamboulis
Alexia Skiadas
Nicole Maniscalco
CONCLUSION
GRANT
HOW TO REMOVE
STEM CELLS
ETHICAL CONCERNS
A comparison of the removal of stem cells from the embryo, baby teeth, and wisdom teeth

The collection of stem cells from wisdom teeth is a new way to study deadly diseases regarding stem cells
The goal is to harvest the pulp layer inside the teeth, jawbone, and periodontal ligament

The removal of the periodontal ligament, extraction of pulp from a drilled tooth, and the secretion of stem cells in the form of an enzyme
FAQ
BENEFITS OF STEM CELLS
INTRODUCTION
The stem cells are able to differentiate into specialized cells

There are two types of stem cells:
Embryonic stem cells
Adult stem cells
The stem cells function as personalized medicine

There are no ethical issues with the extraction of stem cells from baby and wisdom teeth

Baby and wisdom teeth can be properly stored for future use
QUESTIONS
Research: $2,250,000

Salary: $1,500,000

Advertisement: $1,000,000

StemSave Storage: $250,000

Grand Total: $5,000,000
Pathway to the future of research
Harmless, non-invasive procedure
No ethical dilemmas
Latest technology being put to use
Store your stem cells today.
Save your life tomorrow.
THREE MAJOR STEM CELLS IN BABY AND WISDOM TEETH
STORAGE OF
STEM CELLS (PART 1)
The process:
- Tooth collection
- Stem cell isolation
- Stem cell storage
mechanisms
a) Cryopreservation
b) Magnetic freezing
The prices
STORAGE OF
STEM CELLS (PART 2)
What are the Advantages?
Guaranteed donor
Simple and Painless
Pricing: Tooth vs Umbilical Cord
Stem cells have unique uses
Usage for relatives
Precautions before unexpected events
What is SHED?

What makes dental stem cells so unique?

What diseases are being studied in relation to dental stem cells?

Is it ever too late to save stem cells from your teeth?
REFERENCES
Atari, Maher. "Dental pulp of the third molar: a new source of pluripotent-like stem cells." Journal of Cell Science 125.14 (2012): 3343-56. ProQuest Central. Web.

Chadipiralla, Kiranmai, et al. "Osteogenic Differentiation of Stem Cells Derived from Human Periodontal Ligaments and Pulp of Human Exfoliated Deciduous Teeth." Cell and tissue research 340.2 (2010): 323-33. ProQuest. Web.

Hasegawa, Kyoko. "Stem cells from teeth; Another way opened to avoid using embryos." The Gazette (2008). ProQuest Central. Web.

Leong, Wai Khay. "Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms." Stem Cells Translational Medicine (2011): 177-87. ProQuest Central. Web.

Miura, Masako. "SHED: Stem cells from human exfoliated deciduous teeth." PNAS 100.10 (2003): 5807-12. ProQuest Central. Web.

Mori, Giorgio. "Osteogenic Differentiation of Dental Follicle Stem Cells." International Journal of Medical Sciences (2013): 480-87. ProQuest Central. Web.

Tasker, Fred. "Teeth offer potential source of stem cells." General Interest Periodicals (2011). ProQuest Central. Web.

"Stem Cell Research; Baby and Wisdom Teeth could be Banked for Future Stem Cells." Life Science Weekly (2005): 1586-. ProQuest Central. Web.
REFERENCES
http://www.mensfitness.com/sites/mensfitness.com/files/imagecache/node_page_image/blog_images/x-ray-cancer_main.jpg

http://centerfordentalimplants.info/wp-content/uploads/2012/09/illustrated-tooth-with-fluoride-protection.jpg

http://www.robertonavarro.com.br/home/images/stories/palestra.jpg

http://s7d2.scene7.com/is/image/Fathead/dental_cross_section-tooth_labeled_medium_prod?layer=comp&wid=444&hei=444&fmt=jpeg&qlt=95,1&op_sharpen=1&resMode=bicub&op_usm=0.5,0.2,0,0&iccEmbed=0&bgc=0xdedede&bgColor=0xdedede

http://www.hellomagazine.com/imagenes//healthandbeauty/mother-and-baby/2012111610034/stem-cell-banking-baby-child/0-50-553/cell-freezing--z.jpg

http://www.sigmaaldrich.com/etc/medialib/life-science/stem-cell-biology/mesenchymal-stem-cell.Par.0001.Image.457.gif
STRUCTURE OF MOUTH AND TEETH
Figure 1. Three major stem cells.
Figure 2. Structure of the mouth and teeth.
Figure 3. Storage of stem cells.
Osteoblasts, adipocytes, and
chondrocytes are derivatives of mesenchymal stem cells.
An
internal view of the mouth and cross section of the wisdom tooth.
A researcher is properly storing stem cells in freezing temperatures.
Figure 4. Grant proposal costs.
The pie chart displays the financial
breakdown of a $5 million budget for the investment in research, salary, advertisement, and StemSave storage.
Full transcript