Hematopoietic Stem Cells

Hematopoietic Stem Cells About Uses/Process - recently have been able to coax the cells from the marrow to the blood in greater numbers by injecting a cytokine (granulocyte-colony stimulating factor)

- Used for bone marrow transplants (HSCT)- small number of HSC can generate a much larger amount of daughter cells.

- replacement therapy for hard to treat blood conditions which inhibit their ability to fight of disease and infection. (eg. leukemia )
Sources http://www.rndsystems.com/molecule_group.aspx?g=2122&r=7
http://www.stemcell.com/en/Products/Cell-type/Hematopoietic-stemprogenitor-cells.aspx
http://www.ncbi.nlm.nih.gov/pubmed/14734086
http://stemcells.nih.gov/info/scireport/pages/chapter5.aspx
http://www.mazecordblood.com/fetal-stem-cell.php
Possible Treatment - promise of the drug vorinostat, an anti-cancer drug known as a histone deacetylase inhibitor

-it would turn off the enzyme that lead to inflammation after the transplant.

-Side Effects:
- Development of graft-versus-host disease
-To help prepare the body, patients receive prophylactic therapy (series of drugs)
-multipotent and self-renewing progenitor cells
-creates types of blood cells from myeloid (spinal cord) and lymphoid (circulatory system)
- Can be obtained from iliac area of the pelvis using a special needle and lsyringe
-Sources; Bone marrow, Peripheral blood, Umbilical Cord Blood, Fetal Hematopoietic System, and Embryonic Stem Cells and Embryonic Germ Cells
-Dr. Irving Weissman: first successful scientist to isolate HSC