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Transcript of Alprazolam
Uses and Side effects
Benzodiazepines cause a
dose-related CNS depressant activity by binding at stereo specific
In vitro, alprazolam is
bound (80%) to human
Alprazolam and its metabolites
are excreted primarily in the
Binding to GABA-A receptor
Enhancing the GABA inhibitory effect
membrane permeability to chloride ions
Dose and Regimen
Therapy should be initiated at a low dose to minimize the risk of adverse responses.
Adult dose: 0.25-0.5 (mg) 3 times a day.
When it is combined with other central nervous system depressants, such as opiates or alcohol.
• Low blood pressure
• Shallow breathing
• Impaired motor function
• Muscle weakness
So how to withdraw Alprazolam safely?
Reducing medication slowly over a period of eight weeksover
Pregnancy and Lactating
Alprazolam cross the placenta
Neonatal flaccidity and respiratory problems have been reported in children born of mothers who have been receiving Alprazolam.
with Other CNS Depressants
Causes additive CNS depressaning effects when co-administered with other psychotropic medications :
Drugs affecting Cytochrime P453A enzymes
• Azole antifungal agents
They increase plasma alprazolam concentrations
HIV protease inhibitors
Low doses of ritonavir resulted in a large impairment of alprazolam clearance
They have very rarely been associated with increased intraocular pressure.
Alprazolam metabolized by the liver, and the metabolites are excreted in the urine.
apidly absorbed with nearly complete bioavailability.
The plasma half-life has ranged from
In obese patients
---> Half-life may be prolonged.