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Defence against disease

Immunology (Physical barrier and Innate immune system)

Sergi Fluvià Sabio

on 8 June 2013

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Transcript of Defence against disease

DISEASE Three lines of defence Intestine enzymes 2 3 1 Phsysical barrier Mechanisms Mucus Ciliated cells Vagina acid Lysozymes Intestine enzymes Skin Epithelial surface Types of response to the presence of a bacterial pathogen Secretion of antimicrobial peptides (defensins) Inflammation Activation of the complement system Defensins disrupt the membrane of the pathogen and kill the cell Isolation of the injured and stopping of the damage What is it? Plasma proteins. They form complexes to open pores in the pathogen, and consequently bacteria die. Caused for: Bacteria A bigger pathogen Macrophage recognise bacteria through receptors Salmonella typhimurium Mast cells are activated Two things happens Macropages phagocyte Secrete chemokines They secrete histamine What do the cytokines and histamine do? Dilate local blood vessels Increase the permeability More blood goes to the zone More fluid leaks to the tissue Secrete cytokines Monocytes Neutrophils Macrophages Ancylostoma duodenale Macrophages and neutrophils cannot engulf them Other method Macrophages Neutrophils Eosinophilis Physical barrier Innate immune system Adaptive immune system Lysosomal enzymes HNP3 dimer (α-defensin) HBD2 (β-defensin) Sergi Fluvià Sabio THANK YOU! http://arstechnica.com/science/2010/09/salmonella-causes-then-feeds-off-gut-inflammation/ Salmonella causes, then feeds off gut inflamation
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