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cis-AB프레젠테이션 자료

생물 발표자료
by

Sangmin Kim

on 27 November 2012

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Transcript of cis-AB프레젠테이션 자료

Diagnosis *Differential diagnosis
If the child of an AB and an O individual is O , then a rare alternative possibility is that the parents were carriers (heterozygous) for the Bombay phenotype (Hh) and the child is a Bombay (hh) homozygous by genotype thus expressing Bombay phenotype also called Oh where irrespective of the presence of the ABO alleles the substrate from which those antigens are made is not made and thus A, B and even O antigen is completely absent. Scenario When one parent carries a Cis AB allele, the other allele can be any of O, A or B and the phenotype of this parent is anyway AB Cis-AB Paternity/maternity dispute For example a child of a cis AB (who will apparently look as a regular AB phenotype*) individual and an O individual will be either AB or O instead of the usual A or B Only seen in Korea cis-AB is appears only in Korea and Japan Feelings 10207 1020-7~12 1-2 2 Group 2 definition : a rare ABO Blood group antigen genotype which is phenotypically almost the same as AB Features 1. Scenario
2. Diagnosis/transfusion
3. Paternity/maternity dispute
4. Only seen in Korea
5. Feelings but the children will inherit either the AB or the other allele from this parent. Examples: If the other parent is O phenotype (OO genotype) there can be three likely scenarios for blood group of children of a Cis AB carrier (and a 4th very unlikely scenario):
The second allele is O: children are either AB or O
Second allele is A: Children are either AB or A
Second allele is B: Children are either AB or B
A very rare 4th possibility exists: if the other allele is also Cis AB then the children will be always AB irrespective whatever the other parent is, because they will have one cis AB allele from this parent. If the other parent is A, depending on whether this parent is genotypically AA or AO and what the other allele is in the Cis Ab carrying parent, there are following possible scenarios:
Other parent is AO and second allele is O: The children are either AB or A or O
Other parent is AA and the second allele is O: The children are either AB or A
Other parent is AO and second allele is A: The children are either AB or A
Other parent is AA and the second allele is A: The children are either AB or A
Other parent is AO and the second allele is B: The children are either AB or B
Other parent is AA and the second allele is B: The children are always AB
Rare situation: If the other allele is also cis AB:The children are always AB Like wise there will be similar scenarios for the other parent being B:
Other parent is BO and second allele is O: The children are either AB or B or O
Other parent is BO and second allele is A: The children are either AB or A
Other parent is BO and the second allele is B: The children are always AB or B
Other parent is BB and the second allele is B: The children are either AB or B
Other parent is BB and the second allele is O: The children are either AB or B
Other parent is BB and the second allele is A: The children are always AB
Rare situation: If the other allele is also cis AB:The children are always AB Error in the dividing process : cis-ab appears by mutant allels in the dividing process of the chromosomes, both the A and B alleles can be located in the same chromosome if a parent has a cis-AB allele, his or her phenotype is anyway AB In case of a normal A and B,
the baby is born either A or B If a parent has a cis-AB allele,
a baby that shows an AB phenotype,
or O can appear(rare possibility : if both one parent has
two cis-AB allele, AB will always appear in the next
generation) the antigenicity of either A or B can be very weak, so
the subject can be diagnosed as either A or B (often diagnosed as A)-sometiems the antigenicity for both can be weak, thus can be diagnosed as O

-may need to seperate the chromosome and diagnose it When the father has an A phenotype and the mother has an O phenotype, whereas the child has an AB phenotype, the father may need to run a test for blood diagnosis Transfusion: ex) When the subject is identified as A, the antrogenicity for blood type A is extremely weak - alpha antrogen will not work as an antigen when exposed to blood type A fully, as blood type B would perform

can receive transfusion of blood; A, O, and cis AB -will work the same for subjects identified as blood type B may lead to a possible maternity dispute! *a parent may appear as an A or B phenotype
due to poor testing Even in Japan, Areas
close to the Bekjae cultural area are shown cis-AB blood types In Korea, most of the cis-AB are in the Southwest areas; Bekjae cultureal area Korea : 3.5/100,000 Southwest(Jeon-nam) : 50/100,000 The relationship betweenancient Korea and Japan has been scientifically proven 10208 10209 10210 10211 10212 Thank you It was interesting to know
that such blood type existed.
I want to know more
about rare blood types I'm surprised to know that
a person who has such
a rare blood type exists
in this classroom! It was very fun to
know about cis AB I hope my son is not cis-AB It was fun.
It was really educational It was interesting to investigate about this topic
Full transcript