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cancer de mama
Transcript of cancer de mama
Angélica Patricia Hurtado Duque
María Fernanda Salazar Robayo RISK FACTORS THAT CAN NOT BE MODIFIED
Genetic factors: BRCA1 and BRCA2
Personal history of Breast Cancer
Dense breast tissue
Breast radiation early ETIOLOGY LIFESTYLE
Not having children or having them at a later age
Recent use of oral contraceptives
Post-menopausal hormone therapy (PHT)
Not breastfeed babies
Lack of exercise Cancer is a broad term for a class of diseases characterized by abnormal cells grow and invade that healthy cells in the body.
Breast cancer is the most common cancer in women in both developed and developing countries. The incidence of breast cancer is increasing in the developing world due to increased life expectancy, increased urbanization and adoption of western lifestyles. Breast Anatomy Breast cancer can occur in men of any age, but usually is detected in men 60 to 70 years. The male breast cancer accounts for less than 1% of all cases of breast cancer.
You may find the following types of male breast cancer:
Infiltrating ductal carcinoma
Ductal carcinoma in situ
Paget's disease of the nipple BREAST CANCER IN MEN Growing older
Taking hormonal medicines
Having been exposed to estrogens in the environment
Being heavy users of alcohol
Having liver disease, which usually leads to lower levels of androgens and higher levels of estrogen
A strong family history of breast cancer or genetic alterations
Radiation exposure The Risk Factors for Male Breast Cancer A lump felt in the breast
An inverted nipple
Nipple discharge (clear or bloody)
Sores on the nipple
Enlarged lymph nodes under the arm
It's important to note that enlargement of both breasts is usually NOT cancer. The medical term for this is gynecomastia. Sometimes the breasts can become quite large. Non-cancer-related enlargement of the breasts can be caused by medications, heavy alcohol use, weight gain, or marijuana use Symptoms of Male Breast Cancer PHYSIOPATHOGENY CLINICAL SIGNIFICANCE MORPHOLOGICAL CHANGES Phyllodes Tumor ILC – Invasive Lobular Carcinoma LCIS – Lobular Carcinoma In Situ Paget's Disease of The Nipple Papillary Carcinoma Colloid Carcinoma IDC – Invasive Ductal Carcinoma Tubular Carcinoma Medullary Carcinoma IDC – Invasive Ductal Carcinoma Histological appearance Macroscopic appearance IDC – Invasive Ductal Carcinoma Papillary type Cribriform type DCIS – Ductal Carcinoma In Situ Histological appearance of comedocarcinoma Macroscopic appearance of comedocarcinoma DCIS – Ductal Carcinoma In Situ HISTOLOGY THINGS NOT INCREASE THE RISK OF BREAST CANCER Antiperspirants
Implants AMERICAN JOINT COMMITTEE ON CANCER STAGING
Location: Chromosome 17q21
Codifies a nuclear protein of 1863 amino acids, with pleiotropics activities
Function: detection, signposting and repair of injuries of the DNA connected to the transcription and activity of the ubiquitina ligasa
, Mutations: inheriteds autosomal dominant by variable penetration, are associated.
Breast tumors that harbor mutations of BRCA-1 often lack of estrogen and progestin receptors.
BCRA1 has 29 exons BRCA1 Location: chromosome 13q12
Encodes a protein of 3418 amino acids involved in DNA repair.
Function: is associated with breast cancer in men and in women.
Breast tumors that harbor mutations of BRCA-2, have frequently estrogen receptor positive and tend to be seen in older age.
It has 27 exons BRCA2 OTHER GENES LI-FREUMENI's SYNDROME owes To Itself to mutations in the line germinal in the gene of tumour suppression (antioncogene) p53 Location: 17p13 The risk of suffering cancer of breast associated with this syndrome this one increased in 50 %. GENE PTEN Location: 10q22-23 Function: Syndrome of Cowden suppression tumor, it is a autosomal dominant disorder characterized by multiple benign hamartomas and malignant tumors (cancer of breast). In the personas that they have syndrome of cowden the risk of suffering cancer increases in 50 %.. CHECK-2 Gene of kinasa of control of the cellular cycle constitutes an important component of the route of repair of the cellular DNA. The mutation of the gene duplicates the risk of cancer in women and multiplies it by 10 in the men. BREAST CANCER BIBLIOGRAPHY Lynn C. Hartman, Charles L. Loprinzi CLINICA DE MAYO. Guia de cáncer en la mujer.
Dennis A. Casciato; Mary C. Territo MANUAL DE ONCOLOGÍA cLÍNICA. Ed. Lippinicott Williams & Wilkins
Vicent I. DEvita Jr; Theodore S. Lawrence. CANCER PRINCIPLES & PRACTICE OF ONCOLOGY. 9th Edition. Ed. Lippinicott Williams & Wilkins. 2011