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La depresión

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Mireia Llevadot

on 28 May 2015

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Transcript of La depresión

LA DEPRESIÓN
Soledad
Soledad, usted tiene Depresión Mayor
BDNF
SERTRALINA
Andrey Krendzel
Mireia Llevadot Sesmilo
Gabriela López Pérez
Ana Ruiz Heredia
Mamá, no tengo hambre, tengo dificultades para concentrarme, lloro sin motivo, tengo insomnio y me he alejado de mis amigos.
Hasta he dejado de preocuparme por mi aspecto físico y la higiene.
Ve al médico, hija
Soledad, soy tu psiquiatra y te ayudaré a entender lo que es la Depresión Mayor. Mañana empezaremos con el tratamiento.
TEORÍA DE LAS NEUROTROFINAS
¿ Relación con la serotonina?
Polimorfismo BDNF
Val166Met
Interacción Epistática
Características Moleculares
(Brain Derived Neurotrophic Factor)

TEORÍA SEROTONINÉRGICA
5-HT
5-HT1A
Raphe nuclei
Regiones cortico-
limbicas
5-HT1A
5-HT1A
Serotoninergicas
Inhibidor (potasio)
Feedback
negativo
Autoreceptores
feedback negativo
Polimorfismo
C(1019)G
Referencias
Berger M et al. The expanded biology of serotonin. Annu Rev Med. 2009;60:355-66.

Marije aan het Rot et al. Neurobiological mechanisms in major depressive disorder. CMAJ. 2009; 180(3): 305–313.

Wikipedia Serotonin. http://en.wikipedia.org/wiki/Serotonin

Wikipedia 5-HT1A receptor. http://en.wikipedia.org/wiki/5-HT1A_receptor

Wayne C. Drevets et al. Serotonin Type-1A Receptor Imaging in Depression. Nuclear Medicine and Biology. 2000; 27 :499–507.

Brice Le François et al. Transcriptional regulation at a HTR1A polymorphism associated with mental illness. Neuropharmacology. 2008; 55: 977–985.

Sean P. David et al. A Functional Genetic Variation of the Serotonin (5-HT) Transporter Affects 5-HT1A Receptor Binding in Humans. The Journal of Neuroscience. 2005 ; 25(10):2586 –2590.

A. Strobel et al. Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm. 2003; 110: 1445–1453.

Sylvie Lemonde et al. Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide. The Journal of Neuroscience. 2003 ; 23(25): 8788 – 8799.

Yung-yu Huang et al. Human 5-HT1A receptor C(x1019)G polymorphism and psychopathology. International Journal of Neuropsychopharmacology. 2004; 7: 441–451.



Benarroch EE1. Brain-derived neurotrophic factor: Regulation, effects, and potential clinical relevance. Neurology. 2015;84(16):1693-704.

Z.M.Ignacio, G.Z. Réus, H.M. Abelaira, J.Quevedo. Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. Neuroscience 2014;275: 455-468

Bun- Hee Lee, Yong-Ku Kim. The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatmen. Psychiatry Investig 2010;7:231-235.

L. Musazzi, JM Rimland, A Ieraci, G Racagni, E Domenici and M Popoli. Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. International Journal of Neuropharmacology 2014;17:779-791.

Uniprot BDNF http://www.uniprot.org/uniprot/P23560

Pharmaceutical Intelligence BDNFhttp://pharmaceuticalintelligence.com/2012/12/05/monoamine-neurotrophic-factor-pharmacokintic-hypotheses-of-depression-old-and-newer-treatments/

Wikipedia BDNF http://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

Wikipedia Neurotrofina http://es.wikipedia.org/wiki/Neurotrofina

Monografías BDNF http://www.monografias.com/trabajos85/factor-neurotrofico-derivado-cerebro/factor-neurotrofico-derivado-cerebro.shtml

cromosoma 5
7TM
promotor
Celada P, Puig V, Amargós-Bosch M, Adell A, Artigas F. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. Rev Psychiatr Neurosci 2004;29(4):252-65

Mann JJ. Role of the Serotonergic System in the Pathogenesis of Major Depression and Suicidal Behavior. Neuropsychopharmacology 1999:21, 99–105

Psychopharmacology Institute, Mechanism of Action of SSRIs. http://psychopharmacologyinstitute.com/antidepressants/ssris/mechanism-action-ssris/
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