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Antithrombotic Herbs

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on 2 December 2013

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Transcript of Antithrombotic Herbs

Objectives
natural supplements used to REDUCE the risk of thrombosis.
Morphology of herbs.
Active constituents , pharmacology ,side effects and dosage form of herbs
What is thrombosis ?
Your body is designed to heal itself. When the vascular system is injured the body responds quickly to stop the bleeding and repair the damage. Circulating platelets are called into action to quickly seal the leak by forming a blood clot.

Not all blood clotting is desirable. Thrombosis is an abnormal blood clot inside a blood vessel. It is a pathologic condition that occurs when the body forms arterial or venous blood clots that are excessively large and obstruct blood flow. The blood clots can also detach from the vascular wall and travel in the blood. These free floating thrombi (now called emboli) can lodge anywhere in the cardiovascular system, including the lungs or brain (as in a thrombotic stroke).

natural supplements used to REDUCE the risk of thrombosis.
1-Garlic.

2-Ginger.

3-Curcumin (turmeric).

A strongly scented herb belonging to genus Allium of the family Liliaceae

Garlic
Active Constituents:
Anti Thrombotic Herbs
Morphology:

plants have flat, grayish-green leaves, which grow 1-2 feet ,during bloom period, the plants send up slender stalks which produce edible flowers in a round, white bulb.Single bulb is composed of 8 to 12 sections called cloves, which are held together by parchment-like covering.
i. Volatile oil with SULFR containing compounds
ii. Alliin allicin
iii. glutathione.

synthesis of nitric oxide, a chemical messenger that inhibits platelet aggregation and vasodilates blood vessels.
Garlic
Pharmacology
dose and dosage form :

Heartburn
Nausea
Flatulence, diarrhea, vomiting, distress
GI disturbance
Allergic reactions
Body and Breath odor
Headache, insomnia, fatigue, & vertigo
Topical Garlic may cause skin irritation
Stimulates asthma, shortness of breath
Tachycardia (increased heart rate)

2 to 5 g of fresh raw garlic .
0.4 to 1.2 g of dried garlic powder.
2 to 5 mg garlic oil.
300 to 1,000 mg of garlic extract

intro.
Ginger

Morphology
ginger root is the rhizome of the plant Zingiber officinale, its name to its genus and family (Zingiberaceae). Aromatic, pungent and spicy, ginger adds a special flavor. the ginger rhizome can be yellow, white or red in color, depending upon the variety. It is covered with a brownish skin that may either be thick or thin
turmeric
Curcumin
morphology
widely cultivated tropical plant of India having yellow flowers and a large aromatic deep yellow rhizome; source of a condiment and a yellow dye. The root and rhizome (underground stem) are used medicinally.
Active constituent :
1- Coloring principles known as curcuminoids (mainly curcumin)
2- Volatile oil (zingiberene)
3- Sugars and starch.

- The mixture of zingerone, shogaols and gingerols is behind the special smell and flavor that distinguish ginger.

-Ginger is known with its little spicy taste, this spice comes from a compound called phenylpropanoid.

- 3% of ginger’s chemicals are made up from oil that is composed of 200 chemical substances such as:
(Borneol , Camphene , Citral ,Eucalyptol . Linalool , Phenllandrene, Zingiberine and Zingiberol phenols)


-carbohydrates, lipids, proteins, minerals, vitamins, phosphorus, potassium, riboflavin and vitamin C.


Active constituent :
Pharmacology
if you have
gallstones
or any other disease of the gallbladder;
if you have
diabetes
or if you are taking a medicine to control your blood sugar level.
If you have any
heart problems
or take any heart medicines;
If you have a
bleeding or blood clotting disorder
or are taking a medicine to increase or decrease the clotting of your blood such as aspirin, warfarin (Coumadin), or heparin
If you take other herbs, antioxidants, or health supplements (these may affect blood thinning).

Contraindication

1-include mild GI effects such as heartburn, diarrhea, and mouth irritation.





2-Allergic reactions to ginger generally result in a rash.



Side effect:
`
dose and dosage form :
Ginger has been used in clinical trials in doses of 250 mg to 1 g, 3 to 4 times daily.
Pharmacology:
it has been shown to reduce platelets from clumping together, which in turn improves circulation and may help protect against atherosclerosis.
-turmeric is generally safe.
-It has been used in large quantities as a condiment with no adverse reactions.
-Some herbal books recommend not taking high amounts of turmeric during pregnancy as it may cause uterine contractions .
-people with gallstones or obstruction of bile passages should consult their healthcare practitioner before using turmeric.
-there were no well-known drug interactions with turmeric.
Side effects
Dose and Dosage Form :
Turmeric extracts standardized at 90 to 95% curcumin can be taken in the amount of 250 to 500 mg three times per day.


Tincture, 0.5–1.5 ml three times per day
http://www.drugs.com/mtm/ginger.html
http://www.drugs.com/npp/ginger.html
http://en.wikipedia.org/wiki/Ginger
http://www.truestarhealth.com/Notes/2175005.html
http://www.walgreens.com/marketing/library/finddrug/druginfo1.jsp;jsessionid=FggTy1VL+MzJpQnce7tMEQ**.p_dotcom72?particularDrug=Garlic&id=15980
http://www.drugs.com/npp/garlic.html
http://www.sigmaaldrich.com/life-science/nutrition-research/learning-center/plant-profiler/zingiber-officinale.html

Ginger has been shown to inhibit platelet aggregation and to decrease platelet thromboxane production in vitro
References
Done by
Afnan ALjehani
Muneerah saad
Ruba ALtowrge
Reem Fahad

Adverse Effects:
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