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Protein Function,Myoglobin and Hemoglobin

Molecular difference between normal and sickle cell forms of hemoglobin

https://www.google.com/search?q=diagram+of+the+amino+acid+difference+in+sickle+cell+anemia&source=lnms&tbm=isch&sa=X&ei=7X-LU53WJtLmsATJ64CQBg&ved=0CAYQ_AUoAQ&biw=1366&bih=624&dpr=1#facrc=_&imgdii=_&imgrc=y3s0dSXSjw5U0M%253A%3BqOkwMHQP3lUzgM%3Bhttp%253A%252F%252Fbiochemmarie.files.wordpress.com%252F2013%252F04%252F437300.gif%3Bhttp%253A%252F%252Fbiochemmarie.wordpress.com%252Fpage%252F3%252F%3B316%3B193

Difference between normal and sickle red blood cells

The Bohr effect for the association and disassociation of oxygen and hemoglobin

https://www.google.com/search?q=diagram+of+the+amino+acid+difference+in+sickle+cell+anemia&source=lnms&tbm=isch&sa=X&ei=7X-LU53WJtLmsATJ64CQBg&ved=0CAYQ_AUoAQ&biw=1366&bih=624&dpr=1#q=diagram+of+difference+between+normal+and+sickle+red+blood+cells&tbm=isch&facrc=_&imgdii=_&imgrc=uBor3ieZjR44QM%253A%3BaWkRs-lKvectdM%3Bhttp%253A%252F%252Fwww.mudphudder.com%252Fwp-content%252Fuploads%252F2008%252F11%252Fnormal-and-sickle-cell-rbc-sem.jpg%3Bhttp%253A%252F%252Fejgorgas.edublogs.org%252F%3B1131%3B525

The Bohr effect relates to the association and disassociation because, Christian Bohr, a scientist uncovered the factors that allows hemoglobin to release and bind oxygen. (tense and relaxed states of hemoglobin). One of the main factors he uncovered was PH, he found that a lower PH causes the releasing of oxygen inhemoglobin while a higher PH causes the binding of oxygen to hemoglobin proteins in red blood cells.

Sickle cell anemia

Diseased cells v.s Normal

Oxygenated v.s Deoxygenated Hemoglobin

Sickle cell is inherited from parents to the child the same hair or eye color is passed down. for example from (http://www.stjude.org/stjude/v/index.jsp?vgnextoid=9454db6324d6f110VgnVCM1000001e0215acRCRD) a one parent with a sickle cell trait has a 50% chance of passing is down to their children while two parents with the sickle cell trait have a 25% chance of passing it to the children.

Sickle cells have a crescent moon shape caused by the mutation in the protein make up. They differ from normal red blood cells because they crescent moon shape is not able to carry oxygen well causeing anyone with sickle cell anemia to be in constant pain because of lack of oxygen being delivered to their tissues.

Oxygenated

  • Formed through the transportation of oxygen to cells in tissues
  • Oxygen binds with the heme protein in hemoglobin
  • Taut (tense) and R (relaxed) are two states of hemoglobin at which deciding factors allow oxygen to either bind easier or release

Deoxygenated

  • Is not bounded to oxygen
  • Has a higher absorption spectra (radiation) of 940 nm
  • The 940 nm cause the blue/purple color when the body does not have a sufficient amount of oxygen supply
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