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The Bohr effect relates to the association and disassociation because, Christian Bohr, a scientist uncovered the factors that allows hemoglobin to release and bind oxygen. (tense and relaxed states of hemoglobin). One of the main factors he uncovered was PH, he found that a lower PH causes the releasing of oxygen inhemoglobin while a higher PH causes the binding of oxygen to hemoglobin proteins in red blood cells.
Sickle cell is inherited from parents to the child the same hair or eye color is passed down. for example from (http://www.stjude.org/stjude/v/index.jsp?vgnextoid=9454db6324d6f110VgnVCM1000001e0215acRCRD) a one parent with a sickle cell trait has a 50% chance of passing is down to their children while two parents with the sickle cell trait have a 25% chance of passing it to the children.
Sickle cells have a crescent moon shape caused by the mutation in the protein make up. They differ from normal red blood cells because they crescent moon shape is not able to carry oxygen well causeing anyone with sickle cell anemia to be in constant pain because of lack of oxygen being delivered to their tissues.
Oxygenated
Deoxygenated