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Exploring Synthetic Biology

Overview of Synthetic Biology concepts Description of S&T iGEM Team

Missouri S&T iGEM Team

on 4 May 2013

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Transcript of Exploring Synthetic Biology

Exploring Synthetic Biology EPF Lausanne 2010 Project Applying engineering to biological systems Making interchangable parts for genetic engineering Applications in medicine, materials, agriculture, bioremediation, energy, and more International Genetically Engineered Machines International collaboration to create an open gene library full of standardized biological parts for genetically modifying organsims

30 countries participate iGEM Competition Categories Health or Medicine
Food or Energy
New Application
Foundational Advance
Information Processing
Entrepreneurship Freiburg Bioware 2010: Customizing a Virus for Personalized Medicine Missouri S&T iGEM History of Synthetic Biology The beginnings Interdisciplinary Focus Accomplishments Future Direction and Goals The Basics Beginnings Advancement Concepts first described in early 1900's

Made possible with the discovery of restriction enzymes and the development of gene sequencing in the late 1970's Field developed rapidly along with the perfection of molecular genetics techniques

Success pioneered in part by the iGEM Design Team competition Team formed in 2006

Ethanol Sensor Project

Microbial Fuel Cell Project Biological systems can be applied to every major on campus

Need engineers to help the team design applications prototypes

Need computer science majors to design our Wiki and website

Need science majors to help design DNA

Need social science majors to design public education tools Joined the SDELC (Student Design and Experiential Learning Center)
Created Lab Training Program and Lab Manual, fully integrated into Blackboard
Obtained our own lab space Fall 2010
Created an awesome team mascot: Joe Microbe
Received outside funding
Grown >50% in membership
Organized Bio 375 - Biological Design and Innovation
Successful fundraising
Hosted seminars and put on educational events
Increased networking with other departments Educate public about Synthetic Biology

Expand summer research program and engage in meaningful projects to advance synthetic biology

Earn gold medal at regional competition

Advance to iGEM World Competition

Increase membership diversity

Provide official lab training for all members o Capsid proteins
o Targeting molecules
o Tumor-specific promoters
o Prodrug-activating enzymes • Readily assembled for gene delivery
• Non-replicative
• Successfully targeted and killed cancer cells in vitro • Created a virus construction kit
• Customizable Team Groningen: Heavy Metal Cleanup Accumulation is achieved by disrupting the detoxification process
Metal sensing gene began producing gas vesicles when aresenic was present
Bacteria floated to surface and could be removed Missouri Miners: Microbial Fuel Cell Geobacter metabolism process naturally produces electric current in anaerobic environment
Genes transfered into aerobic bacteria to increase practicality and efficiency of system
Electrons can be harvested from bacteria and used to power a "bio battery" University of Washington: BioBrick-a-Bot Lego Robot for Automated BioBrick DNA Assembly
Commercial Liquid Handling Systems are extremely expensive
BioBrick assembly on a platform that can itself be easily replicated
Lego system can fill 96 well plate
The modular design of LegoRoboBricks allows even small labs access to sophisticated equipment
Costs $700 instead of $10,000 Make genes easily interchangable

Like lego blocks...

Makes process more efficient and innovative Standardizing DNA BCCS-Bristol: Fertilizer Sensor Created a sensor that detects nitrogen
Sensor glows when soil is has adequate nutrients
Allows farmers to selectivly fertilize land
Reduces costs and is better for the environment
Team is contracting with agriculture companies to develop prototype into marketable product Arsenic Looked into cleaning arsenic out of water sources
Arsenic molecules transported into cell Special Thanks To Our Donors for this event Color changing cups: Miner Alumni Association Gift Cards: Questions? A Slice of Pie Sponsors: Past Projects Microbial Fuel Cell
Glucose Sensor
Cell Scaffolding Future Project Coal Flue Filtration Missouri S&T Departments of Biological Sciences, Chemistry, and Chemical Engineering
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