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SNMMI 2014

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by

Adrian Ocneanu

on 24 May 2014

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Transcript of SNMMI 2014

So what's wrong with this picture?
What do we want to do?
Model complexity affects test - retest repeatability of myocardial blood flow measurements with 82Rb PET
Adrian F. Ocneanu, Jennifer M. Renaud, Andy Adler, Rob S. Beanlands, Robert A. deKemp, Ran Klein
MBF?
Myocardial Blood Flow
Septal
Anterior
Posterior
Lateral
ABSOLUTE
MBF
quantify MBF accurately.
Why absolute MBF?
an important metric of heart's health
the basis for MFR and ΔMBF
Q&A
How are we measuring MBF?
82Rb PET
a collection of tools for image processing and analysis
Can we improve? Where?
Current Kinetic Modeling Method:
Blood ROI
Spill Correction (SOC)
On
Right Ventricle Blood Correction (RVBC)
Off
Delay (between the left ventricle and the myocardium signal )
Off

Variants:
Uptake ROI
Spill Correction (SOC)
Off
Right Ventricle Blood Correction (RVBC)
On
Delay (between the left ventricle and the myocardium signal )
On

Acknowledgements:
This work was made possible through the generous support of NSERC-Discovery, Carleton University, and the University of Ottawa Heart Institute, particularly its Positron Emission Tomography lab staff, Kim Gardner, May Aung, and Anna Kim.
Previously
left ventricle
left atrium

Currently
early blood pools (vena cava)
Uptake ROI
Spillover Correction
Right Ventricle Blood Correction
Delay between LV and the myocardium signal
Myocardium and blood signals spill one into each other
With SOC:
Without SOC:
The Right Ventricle blood will have a contribution in the myocardium signal
A transport delay exists between the LV and the myocardium

Results:
Conclusions:
used test-retest data

current method is the most robust, given data format (10s x 9, 30s x 3, 60s x 1, 120s x 1, 240s x1)

significant differences for RPC but not r^2

consider reconstructing the data in other binning formats to explore compromise between temporal resolution and image quality
Full transcript