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The Mystery of the Seven Deaths: A Case Study in Cellular Re

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Thomas Kurland

on 7 November 2014

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Transcript of The Mystery of the Seven Deaths: A Case Study in Cellular Re

The Mystery of the Seven Deaths
By: Thomas Kurland and Tim Bui
Similarities/Connections between Individuals
Symptoms include:
- Dizziness
- Confusion
- Headache
- Shortness of Breath
- Vomiting
- Tylenol Usage
- Same neighborhood
- Died from symptoms within hours
- All deaths occurred at night
Family Questions
1. Bottle of Tylenol?
2. Medical records?
3. Prior contact with neighbors?

Autopsy Report
Cell Function Interruption
Function Interrupted: Cellular Respiration
* Yes, this loss of function could lead to possible death as cellular respiration creates energy which is required by the body to perform many types of functions.
Connection between Deaths
Believe that the seven deaths are connected due to...
- Same symptoms
- Same neighborhood
- Same time period
- Occurred rapidly
The oxygen levels in the patients' were above normal levels, which contradicts the "lack of oxygen" cause of death.
Glucose: Reactant in glycolysis which produces Pyruvate, 2 NADH and 4 ATP
Pyruvate: Formed during Glycolysis; a reactant in stage 2 where acetyl-CoA and CO2 is produced
NAD+: Reduced form of NADH
NADH: Product; electron carrier
* Significantly lower NAD+ levels and significantly higher NADH levels.
* Hypothesis: ETC was affected because there was a large amount of NADH and a small amount of NAD+

Cyanide Impact
* Cyanide binds to cytochrome c oxidase of the ETC and prevents the transfer of electrons to oxygen, which is the final electron acceptor
Cyanide and Cellular Respiration
Cyanide does not allow the transfer of electrons to oxygen, so although the oxygen is still present, but it is not doing the required functions.
Possible Solutions?
* We believe that these solutions would not work as it does not counteract the cyanide that is present, and only adds oxygen to the blood, which there is already an excess of.
Cyanide Poisoning?
* Contaminated Tylenol, as a possible result of drug tampering.
* Should lead to reforms in the packaging of various over the counter substances and also strengthen the number of anti-tampering laws.
Subcellular Metabolite Analysis
Role of Cyanide
Full transcript