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TTXpool

www.peptides.de Tetanus toxin pool generation
by

peptides&elephants GmbH

on 14 June 2013

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Transcript of TTXpool

Tetanus toxin (TTX)
Epitope mapping of the TTX sequence
Capping guarantees that all LIPS peptides are part of the target sequence.
Epitope mapping Tetanus toxin
326 LIPS peptides
Pooling
PEP-LIPS synthesis
LIPS peptides are ready to use without HPLC purification step.
PEP-LIPS synthesis yields:
Main product
+

Side products
TTX282
TTX282
TTX34
TTX63
TTX326
TTX74
TTX189
TTX301
TTX1
TTX255
TTX52
TTX3
TTX177
TTX12
TTX112
TTX2
TTX8
TTX222
TTX282
www.peptides.de
PEP-LIPS synthesis
unstimulated
TTX-stimulated
Representative TT-specific CD4+ T cell response in a healthy donor
Immuno-assay by C. Dembek et al.,
Institute of Virology,
Helmholtz Zentrum München,
Germany
Strong CD4 response, in particular IL2 !
Functional composition of TTX-specific CD4+ T cells in 5 healthy donors
CD8 response also significant
Functional composition of TTX-specific CD8+ T cells in 5 healthy donors
Tetanus Toxin Pool
Full transcript