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9-1-1

Rad9 and 9-1-1 complex
by

michelle payne

on 27 April 2010

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Transcript of 9-1-1


Component of the 9-1-1 complex
Checkpoint response to DNA damage
Highly conserved in eukaryotes.
Has diversrse range of functions As an adaptor molecule Rad9 can;
Mediate phosphorylation of effector kinases
Fascilitates amplification of signals following DNA damage
Associate with ds breaks
Acts as damage sensor
Regulation of BER
Direct role in translesion bypass
Promotion of apoptosis
3'-5' exonuclease activity Repression of androgen receptor in prostate cells
Role in de novo synthesis of pyrimidine nucleotides?
Mouse Rad9 essential for embryogenesis Alterations in Rad9 in humans are linked to nonsmall cell lung carcinoma
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