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Transcript of Cystisercosis
degeneration of the cysticercus
. An inflammatory response that occurs in the CNS parenchyma causes
typical of parenchymal neurocysticercosis. As the
parasite becomes encased in a
, which either
MRI and CT-scan of parenchymal cysticerci.
Human back and buttocks exhibiting cysticercosis
CSF findings include
an increase in white blood cell (WBC) count, in a bodily fluid, such as cerebrospinal fluid (CSF)
elevated protein levels
depressed glucose levels
; but these may not be always present.
infection caused by
of the pork tapeworm(tenia solium)
Del Brutto et al defined the diagnostic categories :
in rare cases, patients with numerous parenchymal cysticerci develop a
diffuse cerebral edema termed
Pathologically, cysticercal encephalitis may progress to
50-100 million people are infected with cysticercosis worldwide.
This is probably an underestimate since many infections go undiagnosed.
Neurocysticercosis is one of the leading causes of adult-onset seizures worldwide.
CT scanning and MRI of the brain have greatly improved the diagnosis of neurocysticercosis.
Areas of endemic disease include
Central and South America,
Studies in Latin America and India have noted adult-onset seizures in approximately 2% of the population, with as many as half due to neurocysticercosis.
of the parasite on a
sample from the
of subretinal parasites via
3. Cystic lesions showing the
scolex on CT scans or MRi
Absolute criteria include the following:
Major criteria :
The diagnostic categories that follow pertain to the criteria outlined in the model developed by Del Brutto et al:
Definite neurocysticercosis (1 of the following)
One absolute criterion
Two major criteria plus 1 minor criterion and 1 epidemiologic criterion
Probable neurocysticercosis (1 of the following)
One major criterion plus 2 minor criteria
One major criterion plus 1 minor criterion plus 1 epidemiologic criterion
Three minor criteria plus 1 epidemiologic criterion
can be diagnosed by visualizing parasite in eye by
diagnosis is a sensitive problem and requires
of the infected tissue
CT scan shows both calcified and uncalcified cysts, as well as distinguishing active and inactive cysts.
-caused by the
, or larval, stage of Taenia solium, the pork tapeworm. The clinical syndromes caused by T solium are categorized as either
(cysts in various tissues including the brain) or
(intestinal tapeworm infection
food contaminated with eggs from infected person
:(anus : mouth contamination of food )
:( use of emetics that help distinigration of gravid segment and release of the oncosphere which circulates to reach tissue )
Mode of infection :
: involves the eye, muscle, or subcutaneous tissue.
It is not known whether oncospheres actively migrate to those organs or passively enter tissues during high blood flow.
: cysticercus cellulosa infect the brain tissue.
Clinical diagnosis: according site (on detail)
(1- stool examination 2- csf examination 3- serological examination which include ELISA, EITB)
(1- x ray 2- ct scan 3 –MRI )
The diagnosis of neurocysticercosis relies on
Computed tomographic scans
imaging can provide vital prognostic information and may be diagnostic if a
is not used .
The enzyme-linked immunoelectrotransfer blot (EITB)
is currently the
tool for diagnosis because it has a specificity of 100% and a sensitivity of 94–100%.However, the sensitivity of EITB is lower in the presence of a single cyst (approximately 50%) or calcified cysts (approximately 75%).
Done by :
83 : Mahmoud Hossam el din Elsayed .
84 :Mahmoud Saad Saad Elnadi
85 : Mahmoud Salah Mohammed shehat
86 :Mahmoud Salah Mohammed Saleh
87 :Mahmoud talat Mohammed Elsayed
Under supervision of :
Dr . Wafaa Atef
(CT scan or MRI showing cystic
, enhancing lesions, or typical parenchymal brain
of intracranial cystic lesions after therapy with
Minor criteria :
- Lesions compatible
with neurocysticercosis on neuroimaging studies
- Clinical manifestations suggestive of neurocysticercosis (eg,
focal neurologic sign
s, intracranial hypertension, dementia)
- Positive findings from
and some epidemiologic factors .
1- an inroduction about cysticercosis .
2- understanding the pathogenesis of cysticercosis .
3- epidemiology of cysticercosis .
4- laboratory dignosis .