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Propofol

Cool stuff about a not so cool all the time drug.
by

austin ilg

on 22 April 2010

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Transcript of Propofol

Propofol:
Facts Dangers and Myths Austin Ilg For Starters: Propofol can also be refered to as Diprivan, which is made by Astra Zenica. Propofol is the generic name.
Diprivan is prescription only in the United States and is available in over 50 countries (Wikipedia).
Propofol is inteded for use in three main areas (Astra Zenica):
1) As a general anestetic at the beggining of surgeries.
2) Long term sedation for adults in the ICU.
3) Helping patients achive a "relaxed state" for other procedures
http://upload.wikimedia.org/wikipedia/commons/6/6d/Propofol.jpg
How Propofol Works It works by blocking the receptors in neurons, restricting communication from one to another. It also inhibits the release of sodium from the neurons so they are unable to move signals down their axon (Wikipedia). Propofol specifically targets the GABA(A) receptors. These are the primary inhibitory receptors in the central nervous system (Diprivan). http://en.wikipedia.org/wiki/File:NAchR_2BG9.png This is a cross section of the GABA(A) blocking protein in the GABA(A) receptor. This disabling of communications allows one to fall alseep. A patient must be closely monitored due to the inhibiting effects of Propofol What's in Diprivan (Propofol)? Diprivan is made up of 1% Propofol, 10% soybean oil, 1.2% purified egg, 2.25% glycerol and sodium hydroxide for Ph. The rest is water (Astra Zenica).
http://en.wikipedia.org/wiki/File:Propofol3d.png This is a propofol molecule: 2,6-Diisoprophlphenol or C12H18O (Patient Health Internationl) Under normal circumstances these neurons would preform their everyday tasks, with the dendrite either recieving a signal from another neuron, or from an outside stimulus, and releasing the action potential of the neuron to send the signal down the axon at a rate of 3 m/s to the brain or other part of the body. Propofol is unique in that it doesn't treat a condition, but allows for other medical procedures to occur (Astra Zenica). Common Side effects Upper airway obstruction
Sleep Apnea
Hypoventilation
Dyspnea
Cardiovascular issues (arrhythmia, hypertension, tachycardia nodal)
Nausea/Vomiting
Severe loss of blood pressure
Ophthalmoplegia (inability to open eyes)
Seizures (1 in 47,000)
Change in mood or emotions
Dizziness
Drowsiness
Lack of coordination
Uncontrollable sneezing
Severe allergic reactions (wheezing, redness, itchiness, cough, swelling, pain)
Lactic acidosis
10.8% of users report adverse effects.
All side effects from AstraZenica/Drugs.com
The Popularity of Propofol Propofol has been occasionally used as a recreational drug, however; due to its inaccessability this is not common and most recreational users are doctors or other medical professionals (Wikipedia). Occasional fatalities occur because the patient is not properly supported with their cardiovascular and respritory functions. Some patients are required to be on a ventilator while on propofol (Astra Zenica). Due to its dangers it is almost never administrated away from a hospital. Propofol is first injected into the body either by hypodermic needle or by an existing I.V. Its goal is to put you alseep by blocking signals in the nervous system (Wikipedia). Recreational users have reported mild euphoria, hallucinations, and disinhibition. Most patients complain of "strange dreams" after waking up from propofol. Long term use has been connected to addiction (Patient Health International). Waking Up Once injected propofol begins to degrade
Diprivan has a half life of 30-60 min (Wikipedia).
In most patients, when the amount of plasma that diprivan is affecting in the blood stream drops below 50%, the patient wakes up abruptly (Astra Zenica). Propofol was determined to be the leading cause in pop singer Michael Jackson's death. He was administered a dose of 25mg of propofol by his personal doctor (Wikipedia). http://weblogs.cltv.com/news/local/chicago/michael-jackson-doctor-conrad-murray-photo.jpg http://scrapetv.com/News/News%20Pages/Entertainment/images-3/michael-jackson-waving.jpg Michael Jackson and his doctor, Conrad Murray AstraZenica. (2005). Diprivan Injectable Emulsion Propofol 1% For I.V. Administration. Author. http://www1.astrazeneca-us.com/pi/diprivan.pdf

Diprivan (Propofol). (2010). Retrieved April 20, 2010, from Patient Health International. http://www.patienthealthinternational.com/astrazeneca-medicines/?itemId=1823290

Drugs.com. (2010). Propofol Side Effects. Retrieved April 22, 2010, from http://www.drugs.com/sfx/propofol-side-effects.html

Propofol. (2010). Retrieved April 20, 2010, from Wikipedia. http://en.wikipedia.org/wiki/Propofol References
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