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Microalbuminuria
2
Microalbuminuria and dementia: The HUNT-HMS Study
No dementia
n= 8,981
Logistic regression models with outcome variable dementia=1 no dementia=0.
Supplementary analyses
- Diabetes mellitus-- Yes/No
- BP treatment-- ever/never
Logistic regression
References
Citatioons here
Results
Other interventions
Assessment findings
Statistical analyses
Background
Microvascular abnormalities are seen in Alzheimer disease and vascular dementia brains
Dementia and microalbuminuria
- What has been published?
- Albuminuria nad Dementia in the Elderly: A Community study
Dementia is associated with microvascular disease of the retina
Methods
Selection criteria
HUNT 2 Microalbuminuria
Substudy
Hx HTN and Yes DM
n=605
Hypertension--BP tablet usage never/ever
Dementia
n=26
(AD=10
VaD=9
Mixed=3)
No dementia
n=579
Dementia
n=339
MCI 12
AD 162
VaD 74
Mixed AD/VaD 39
LBD 7
FTD 18
Other 27
Diabetes mellitus--Self report yes/no
Randomized sample
Hx HTN and No DM
n=3,911
Dementia
n=229
(AD=109
VaD=50
Mixed=25)
No dementia 3,682
Microalbuminuria study
Covariates/Confounders
Aims
Invited: 11,515
Did not participate: 1,763
ALL (n=9320)
mean ACR >=30 N=180
<60
>=60
n=146
n=34
9,752
Generally: To study the association between microalbuminuria and incident dementia in a large population based study.
mean ACR <30
>=60 n=5,563
Did not deliver 3 urine samples
n=54
9,698
age (Cont)
sex
education (Cat)
Clinical cov
GFR
Cholesterol
Non fasting glucose
Waist hip ratio
Pregnant, menstruating, hematuria, UVI n=378
More specifically: To study the association between microalbuminuria, chronic kidney disease and incident dementia in a large sample based population.
<60
>=60
n=9,320
ALL
n=3,611
n=5,709
No dementia=8,981
Dementia=339
No dementia
n=3,596
Self report cov
Hx HTN
Hx DM
Hx Stroke, MI, Angina
Hx Smoking
No dementia
n=5,385
Examine an at-risk-population : To study the association between microalbuminuria, chronic kidney disease and incident dementia in a treated hypertensive, non-diabetic vs diabetic subgroup.
Dementia n=15
(AD=6 VaD=4)
Dementia n=324
AD=155 VaD=70 Mixed=39
Phases of Renal Failure