COR140204

ORIGIN

From the calcified alga Corallina officinalis is obtained an aqueous extract which is concentrated in purified sea water via inverse osmosis and then enriched in marine calcium.

Purified Sea Water

Corallina officinalis

BENEFITS

OF CALCIUM

Marine calcium

DISTRIBUTION

TRADITIONAL USES

BENEFITS OF PURIFIED SEA WATER

BENEFITS OF CORALLINA OFFICINALIS

Pink Granit Coast

The great availability of Corallina's calcium would be due to its combination with a specific peptide favoring cellular assimilation. This great availability has been used for long time ago as calcium supplement.

The fronds can be dried and converted to hydroxyapatite, which is a major component and an essential ingredient of normal bones and teeth. So Corallina Officinalis fronds can be used as bone forming material.

The seawater used to concentrate Corallina officinalis extract has been previously concentrated and purified. It therefore present a high concentration of mineral salt that will emphasize the mineralizing properties of Corallina extract.

Corallina officinalis is mainly found on the North Atlantic coasts. For the manufacturing of Coralcium, Codif R&N harvests Corallina officinalis in the area of Bréhat Island on the Pink Granit coast. One of the most beautiful wild place in Brittany.

To avoid damages due to harvest, Corallina officinalis is harvest by diving and hand cut. It is naturally dried before being used for extraction of its mineral content.

Corallina is derived from the Latin corallum meaning “coral”.

Corallina officinalis is a calcareous red seaweed. It forms calcium carbonate deposits within its cells which serve to strengthen the thallus. These white deposits cause the seaweed to appear pink to lilac in color, with white patches where the calcium carbonate is particularly concentrated, such as at the growing tips.

Brehat Island

BENEFITS OF CALCIUM FOR THE SKIN

After being concentrated in sea water, corallina extract is supplemented in marine calcium. The final product Coralcium present a high calcium content (0.5 to 1.5g/L) with multiple benefits for the skin.

BENEFITS OF CALCIUM IN THE EPIDERMIS

BENEFITS OF CALCIUM FOR DIFFERENTIATION

BENEFITS OF CALCIUM FOR KERATINOCYTES COHESION

Numerous calcium-binding proteins have been studied for their activity on cellular growth or on cellular differentiation. These studies demonstrated that calcium regulates activity of some factors (Stoll, 1998), and enzymes necessary for division (Bickenbach, 1998).

Keratinocytes cohesion is linked to calcium dependent proteins as cadherin and catenin. These two glycoproteins are associated in presence of calcium to obtain a structure ensuring the cohesion between two keratinocytes which is called desmosome or adherent junction. Calcium ensures the rigidification of the extracellular part of these proteins and thus there strong association (Jones et al., 1985).

http://www.molbiolcell.org/content/16/7/3236/F11.expansion

http://www.ulysse.u-bordeaux.fr/atelier/ikramer/biocell_diffusion/gbb.cel.fa.103.b3/content/access.htm

CORALCIUM

EFFICACY

Concentrate of natural, marine and bioavailable calcium, CORALCIUM improves cellular vitality, keratinocytes cohesion and cellular oxygenation for anti-ageing and moisturizing properties.

Recommended % of use: 1 to 5%

Inci name : seawater (and) corallina officinalis extract (and) calcium chloride (and) calcium carbonate.

CORALCIUM IMPROVES CELLULAR OXYGENATION

CORALCIUM IMPROVES SKIN COHESION

CORALCIUM IMPROVES CELLULAR VITALITY

Saline buffer + calcium

Protocol: reconstituted human epidermis incubated for 24H with saline buffer, or saline buffer supplemented in calcium, or Coralcium. Cellular vitality is evaluated using MTT method (mitochondrial activity).

For equivalent quantities of calcium, Coralcium is more efficient to enhance cellular vitality than classical source of calcium. This means that the calcium provided by Coralcium has a better bioavailability for skin cells.

RESULTS:

Protocol: cellular oxygenation was evaluated on human fibroblasts cultures. The cells were incubated at 37°C in presence of glucose. The oxygen consumption is determined by measure of oxygen partial pressure in the test medium. Succinate is used as a positive control for the activation of cellular oxygenation.

Succinate is direct substrate of mitochondrial respiratory chain. It’s assimilation immediately trigger cellular oxygenation. Once again thanks to its calcium bioavailability, Coralcium is more efficient. Coralcium promotes cellular oxygenation.

RESULTS:

Protocol: reconstituted human epidermis incubated for 24H with saline buffer, or saline buffer supplemented in calcium, or Coralcium. Cellular cohesion is evaluated by histological observation.

In saline buffer without Calcium, epidermis presented a defect of inter-keratinocytes cohesion and a defect of adherence to the support that provokes an unsticking of the epidermis from the membrane.

After addition of calcium (50 mg/l), the epidermis presented a good cohesion between the epidermal cells, and also a good adherence

to the membrane.

CORALCIUM promoted cohesion between human keratinocytes. Moreover, the morphological aspect of the epidermis was better than conditions with only calcium addition. This results confirmed the previous results obtained for viability.

Saline buffer + calcium