Audio Transcript Auto-generated
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Okay.
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Hi, everyone.
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My name is Jacqueline Vu,
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and today I will be introducing and discussing the biologic drug to pick them up,
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generic for depicts in and how it treats people with a topic
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dermatitis with an emphasis on how it affects their skin's microbiome.
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Before I get into what diplomat is and its mechanism of action,
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I will tell you a little bit about the disease.
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A topic Dermatitis.
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Yeah.
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What is a topic? Dermatitis. It is
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a type of eczema condition, which presents rash like symptoms on the skin.
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It is a chronic condition, and it usually develops an infancy to early childhood.
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Symptoms include inflamed, itchy, scaly, bumpy,
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red and swollen rashes all over the body
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but usually more pronounced.
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Increased areas such as behind the knees, elbows, armpits around the eyes and lips.
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It is a very uncomfortable condition and dramatically affect one's quality of life
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if not treated.
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I personally have had
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a topic dermatitis since I was a baby,
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so I can say it is a day to day struggle to keep my skin happy and rich free.
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A topic dermatitis is caused by a number of factors.
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One
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is an autoimmune response
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skin inflammation occurs due to a misdirected
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immune. Reaction against
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harmless antigens triggers that cause. Flare ups include
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dryness, sweat
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stress, extreme climate conditions of hot and cold,
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spicy foods or other food allergies.
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Another factor is a disruption in the skin's barrier and microbiome.
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Healthy patients have an intact skin barrier and a balanced microbiome,
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which typically means a high level of microbial
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diversity.
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We have learned in class that it is vital to have a high level of micro
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biodiversity in order to ward off dangerous pathogens.
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Those with a topic dermatitis usually have fragile and
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altered skin barriers and unbalanced
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microbiome.
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In addition, researchers has, research has shown that those with
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a topic dermatitis have massive colonization
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of staphylococcus areas on their skin,
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with
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a
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reduced
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amount of microbial diversity
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okay,
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unable to fight off pathogens and an increased amount of colonized staff.
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Various specter on the skin
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a topic dermatitis. Patients are more prone to severe flare ups
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or skin infections if not treated,
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and here are some pictures of, um,
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a staph infection if not treated,
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So this is where do pillow map comes in.
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It is a biologic
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drug which inhibits enter Lukin,
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13
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by binding to a receptor
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The IL for our alpha subunit, shared by the IL four and IL 13 receptor complexes.
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In other words,
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it is an injectable interleukin four receptor alpha antagonized that
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blocks receptors in the body to help lower inflammation that can lead to symptoms.
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In 2019,
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research is conducted
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a study
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to determine the relationship between depiction,
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staff arias and microbial diversity on the skin
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of
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a topic. Dermatitis patients
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Mm hmm.
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Bacterial DNA was examined from swabs collected from patients with
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A topic dermatitis and treated with either do Pillow Mob 200 mg or
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Placebos for 16 weeks.
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What they found was an overall increased abundance in microbial diversity
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and regional and non regional skin, as well as decreased abundance of staff arias.
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This combination contributes
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buttes to less symptoms of moderate to severe A D and can ultimately
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lead to clearer and healthier skin enable to ward off harmful pathogens.
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I believe clinics and hospitals may be able to help those with a
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topic dermatitis if they help patients become aware of this new biologic drug.
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It was approved by the FDA in 2017.
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So while it is fairly new drug.
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It may be able to improve the quality of
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life of those affected with lifelong A topic dermatitis.
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Yes,
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I just