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Audio Transcript Auto-generated
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the timeline of tamoxifen, otherwise known by brand name that
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is Nolvadex or its original compound I D.
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I. C.
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I. 46 474 is one that stretches back to the
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19 fifties.
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It is a derivative of Try Fennel, Ethel Lane and
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demonstrated home and altering effects specifically on Estrin.
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This led to a new pathway of drug discovery that
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would revolutionize the treatment of breast cancer with a combination
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off cyclophosphamide, methotrexate and fewer arrests.
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Chemotherapy tamoxifen initially the greatest decline in case out fatality
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throughout the 19 eighties.
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But what makes him oxygen special?
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Well, first, it is considered a first in class drug,
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the first selective estrogen receptor modulator, or some, and enabled
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specific targeting off our positive cancers.
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A second point is that due to the difficulty of
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treating this cancer, the revolution in treatment and significant impact
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it had on mortality in breast cancer patients resulted in
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I. C I LTD.
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Pharmaceuticals division being presented with the Queen's Award for Technological
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Achievement by the Lord Lieutenant on July 6th, 1978.
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Finally, a unique fact about tamoxifen that, as you will
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see as we walk through the timeline to maximum, was
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initially targeted as a contraceptive, not an anti cancer job.
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And this intention almost led Toa TSI Pharmaceuticals, scrapping the
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development altogether.
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Following icy I 40 46 474 Having not to be
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found to have ovulation inhibiting properties was only to the
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protested resignation off its head scientist, Arthur Walpole.
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The development was picked up again, and thank God it
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waas. In the late 19 fifties, there was a huge
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surge in the research and development of the noble class
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of anti Osun compounds as a potential morning after contraceptive
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pill at the time Imperial Chemical Industries, I See I
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Pharmaceuticals and Arthur Walpole, our reproductive endocrinologist, led a team
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and hopes the developing this new class of contraceptive.
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In 1962 a chemist in both polls research team named
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Dora Richardson was developing derivatives based on a try fennel
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ethylene molecule and synthesized synthesize the world's first compound with
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a name I see.
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I 46474 which would later become tamoxifen, originally to maximum,
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was intended as a no western inhibitor.
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However, during later drug testing trials, it was found that
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tamoxifen had no efficacy as an arrester inhibitor.
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On the contrary, it.
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It's stimulated ovulation in women.
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Further development of tamoxifen was abandoned by I c I
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Pharmaceuticals as a future effort, However, as mentioned before, was
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only picked up once Arthur Walpole insisted that I see
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I 46 474 could be potential therapeutic breast cancer.
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Subsequently, I see 46474 was tried as a breast cancer
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therapeutic and proved to have efficacy in something cancer, cell
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growth and proliferation.
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Unlike conventional drug discovery process, the target for tamoxifen was
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not selected.
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First, in contrast, was discovered after tamoxifen was established as
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a successful cancer therapeutic.
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It was saying that the principal mechanism of the accident
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action off tamoxifen is mediated by its binding to the
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western receptor in the blocking off the proliferated actions off
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your student.
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However, it is also suggested that the anti proliferated active
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of tamoxifen is the induction off the synthesis of side
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akin transforming growth factor Bay by tamoxifen, which acts as
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a negative order crying regulatory molecule