
Audio Transcript Auto-generated
- 00:01 - 00:04
our diseases may not serious disease, which in French means
- 00:04 - 00:06
fiddler. And it's a disease which results in EPA gastric
- 00:06 - 00:08
pain within large goblet cells.
- 00:08 - 00:10
And it is very rare to the plane, which occurrence
- 00:10 - 00:12
of mortality data are, as of yet undetermined.
- 00:13 - 00:14
So on the left, there's a picture of a fiddler
- 00:15 - 00:15
on the right.
- 00:15 - 00:18
There's a scan of a person that is affected by
- 00:19 - 00:19
the Nazis disease.
- 00:23 - 00:26
Some common symptoms that occur alongside of Nazi is disease
- 00:27 - 00:31
are nausea, vomiting, diarrhea, weight loss, a profound loss of
- 00:31 - 00:32
appetite, oedema and anemia.
- 00:33 - 00:35
And so a demon is demonstrated in the middle picture,
- 00:36 - 00:38
and that is an excess of interstitial fluids and the
- 00:39 - 00:40
both the torso and in the limbs.
- 00:40 - 00:42
And so it could be demonstrated by pushing a finger
- 00:43 - 00:45
into the extremity of somebody with a deem A.
- 00:45 - 00:47
And the skin is not elastic, dude, all the fluid,
- 00:47 - 00:48
and you can also see the swelling and the person's
- 00:49 - 00:52
toes. And then anemia is a lack of red blood
- 00:52 - 00:54
cells, and so this is commonly due to a lack
- 00:54 - 00:56
of nutrients and specifically in iron off take from the
- 00:57 - 00:59
person. And in this case, it's due to the difficulty
- 00:59 - 01:02
of up taking and receiving nutrients in the first ineffective
- 01:02 - 01:03
member, not trees.
- 01:07 - 01:09
So some risk factors that have been commonly associated with
- 01:10 - 01:12
menagerie is disease have been very difficult to highlight, so
- 01:13 - 01:15
there have been occurrences and siblings, but it has been
- 01:15 - 01:18
determined to not be hereditary, and it's an acquired condition.
- 01:19 - 01:21
And that is demonstrated by the pedigree on the right
- 01:21 - 01:24
hand side, demonstrating that if a parent has it, it
- 01:24 - 01:26
does not necessarily mean that their offspring will have it,
- 01:26 - 01:30
and not every sibling or offspring that has it passes
- 01:30 - 01:30
it on to their Children.
- 01:31 - 01:34
It has also been observed alongside of transforming growth Factor
- 01:34 - 01:35
A and H.
- 01:35 - 01:37
Pylori infections and with the H.
- 01:37 - 01:40
Pylori. The treatment for it has been shown to mitigate
- 01:41 - 01:43
and reduce some of the symptoms that occur alongside of
- 01:43 - 01:46
Nazi A syndrome, and the H.
- 01:46 - 01:49
Pylori causes ulcers and both the stomach and the small
- 01:49 - 01:52
intestine and so treating that has been shown to reverse
- 01:52 - 01:54
some of the symptoms that occur with many trees.
- 02:01 - 02:04
The changes that take place due to this disease are
- 02:04 - 02:07
the goblet cells in large, which are the mucous cells
- 02:08 - 02:12
and in the stomach, the Ah Rue gay Uh, become
- 02:12 - 02:15
enlarged due to the goblet cells, which creates extra folds
- 02:15 - 02:16
in the stomach.
- 02:16 - 02:20
And these extra folds cause a lack of movement, which
- 02:20 - 02:24
helps break down foods and then the small intestine.
- 02:24 - 02:27
The villa are essentially destroyed by the amount of mucus
- 02:27 - 02:29
that enter the intestines.
- 02:30 - 02:34
Um, as well as the goblet sells pretty much engulfing
- 02:34 - 02:35
the villa.
- 02:35 - 02:38
This causes the small intestines to become smooth, which decrease
- 02:39 - 02:46
the amount of absorption or absorption altogether and on the
- 02:46 - 02:47
cellular level.
- 02:47 - 02:52
In large goblet cells release excess mucus amounts excess amounts
- 02:52 - 02:53
of mucus into the stomach.
- 02:54 - 02:57
The excess mucus causes the pH in the stomach to
- 02:57 - 02:59
neutralize or increase.
- 03:01 - 03:04
This gets rid of the acidity, which helps break down
- 03:05 - 03:08
proteins as well as, ah, what other, larger nutrients.
- 03:09 - 03:13
Ah, when food enters the small intestines, uh, the nutrients
- 03:13 - 03:14
are unable to be absorbed into the body.
- 03:15 - 03:18
This is also due to the villa I being damaged
- 03:19 - 03:22
by the extra mucus as well as the larger macronutrients
- 03:23 - 03:24
not being able to be broken down into micronutrients.
- 03:30 - 03:30
The treatment.
- 03:30 - 03:35
The treatments for these would be dietary changes mainly ah,
- 03:36 - 03:39
increase protein and take like protein shakes, increased protein, increased
- 03:40 - 03:44
meat intake, foods that break down at a higher pH
- 03:46 - 03:46
or initially.
- 03:47 - 03:50
This requires T P N, which is a total protein
- 03:50 - 03:53
nutrient. Ah, this is a tube that normally goes down
- 03:54 - 03:58
the nose, which supplies the stomach with a liquid based
- 03:58 - 04:03
food that could have excess amounts of protein for the
- 04:03 - 04:06
stomach to be able to breakdown, and then for the
- 04:06 - 04:08
rest of the intestinal system to absorb.
- 04:09 - 04:11
And then also we have protein pump inhibitors.
- 04:11 - 04:15
These slow the release of stomach acid or mucus.
- 04:17 - 04:20
So then there are some surgical options that could be
- 04:20 - 04:22
used when trying to treatment.
- 04:22 - 04:23
A tree is disease.
- 04:23 - 04:26
When it's reached a point where it is a distraction,
- 04:27 - 04:29
it's a pain beyond what can be dealt with normally.
- 04:30 - 04:31
So the first of these is a gas tractor, which
- 04:32 - 04:33
is a removal of part of the stomach.
- 04:33 - 04:37
So there are a couple different times of gastrectomy, and
- 04:37 - 04:39
they'd be used depending on what part of the stomach
- 04:39 - 04:41
is most affected by Min Ah trees.
- 04:42 - 04:44
So you can either remove the top half of the
- 04:44 - 04:45
stomach. You can remove the bottom half of the stomach
- 04:46 - 04:47
and any part in between.
- 04:47 - 04:50
And in extreme cases where Menagerie is, has become a
- 04:50 - 04:54
crippling affliction that completely ruins the lifestyle of the effect
- 04:54 - 04:55
afflicted patient.
- 04:56 - 04:58
You can completely remove the stomach if it's become more
- 04:58 - 04:59
of a detriment than it's worth.
- 05:00 - 05:01
And then the other option is a gastro judge in
- 05:02 - 05:04
Austin E and that is attaching the bottom of the
- 05:04 - 05:05
stomach to the top of the judging him.
- 05:05 - 05:07
And so the aim with this is to completely cut
- 05:07 - 05:10
out the drag him from the equation to prevent the
- 05:10 - 05:15
Duato him from releasing the enzymes to neutralize the time
- 05:15 - 05:18
that enters the stomach because it's already been neutralized by
- 05:18 - 05:18
the excess mucus.
- 05:19 - 05:22
So this prevents the kind from developing an alkaline state
- 05:22 - 05:23
and doing more damage to the villa.
- 05:29 - 05:31
Thank you very much, Thank you.