Introducing
Your new presentation assistant.
Refine, enhance, and tailor your content, source relevant images, and edit visuals quicker than ever before.
Trending searches
La recherche participative pour la santé publique
2
=
DNA and Disease
(only one small facet of genomic integrity!)
Genetic bases of many diseases solved...
Hereditary Cancer Examples (rare):
DNA repair enzyme dysfunction
(over 100 potential targets in the human genome)
ex:
BRCA genes, not just breast cancer
also promote risk of
prostate cancer, in men,
and many other cancers.
exs:
ATM, CHEK2, MLH, TP53...
benzopyrene
adduct
A micronucleus
low frequency
<5 /1000 cells
higher frequency
20-50/1000 cells
collaboration with EPFL and
SwissDeCode
MinIon sequencing
Genomic Integrity
Breaks in DNA
combines all the dynamic molecular
details of cells into one 'big picture concept'
the 'comet'
assay
AGiR! projects at Hackuarium aim to
'open source' classic methods of DNA damage detection for participatory research.
Living Instruments
life is complex
Avoiding these is clearly
one way to protect
cells from cancer development!
- they occur directly, from lesions, and during the repair process...
- the comet assay allows quantification of double-stranded breaks in general, while the micronucleus assay shows if a big
piece of chromosome broke off.
FEATURES, not BUGS, are what we
hope to enjoy!
mistakes are common, and sometimes necessary
(exs. immune system, learning)
simplifications can encourage idea uptake and implementation
commons.wikimedia.org/wiki/File:Brokechromo.jpg
for public health, too
?
maybe *you* would like to
join in for such trans-disciplinary projects?!
#OH open lab every Wednesday!
20 Route de Crochy,
1024 Ecublens
ma
Participatory Research
other participatory research projects at Hackuarium
against pollution and for public health!
Montreux Clean Beach Project
Biodesign for the Real World
-plastic lakeshore pollution
-microbial lakewater pollution
-mercury and radiation
- lead soon?
*
OpenFlexure
Easy Experiments?
For 'biohackers' everywhere?
3D
printed
Automatic detection for
micronuclei
comets
Assessment of levels of damage
- baseline (averages)
- 'experimental'
modification of habits
ex vivo experiments
Do It Together!!! Participate!! Act!
vid (later?)->
@Hackuarium, 18May2019
For both bright field for micronuclei and epifluorescence of comets, with similar
panoramas of complete samples by both methods, micronuc&comet,
ultimately to enable...
Cheek Cell Chip
prototype design in
context of...