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Transcript of Fahr's Disease
Fahr's Patient Brain
By Rachel Moyer
- behavior issues/mood disorders
- motor and speech difficulty
- decreased cognition
- hallucinations and schizophrenia
"normal" brain vs. Fahr Patient Brain
- Glucose Uptake
- Blood Flow
- basal ganglia
- gene located on chromosome 14q
- the presence of one neurological disease arises from another disease
- often found in conjunction with Parkinson's disease or schizophrenia
-Makes scientists wonder which came first
What does Fahr's Disease Tell Us about the Brain?
- since the calcification decreases functioning of affected
areas, it is often compared to a brain lesion (calcium
interferes with feedback loops)
- impaired motor function correlated with basal ganglia
- also explains schizophrenic symptoms
- tells us which regions rely on the calcified ones
(functioning in related regions will also decrease)
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Chiu, H. F., Lam, L. C., Shum, P. P., & Li, K. W. (1993). Idiopathic calcification of the basal
ganglia. Postgraduate medical journal, 69(807), 68-70.
Francis, A. F. (1979). Familial basal ganglia calcification and schizophreniform psychosis. The British Journal of Psychiatry.
Geschwind, D. H., Loginov, M., & Stern, J. M. (1999). Identification of a locus on chromosome
14q for idiopathic basal ganglia calcification (Fahr disease). The American Journal of Human Genetics, 65(3), 764-772.
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degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look‐alike?. Movement disorders, 17(3), 563-567.
Wider, C., Dickson, D. W., Schweitzer, K. J., Broderick, D. F., & Wszolek, Z. K. (2009).
Familial idiopathic basal ganglia calcification: a challenging clinical–pathological correlation. Journal of neurology, 256(5), 839-842.
- no true cure, but scientists are researching the effects of
- treat underlying diseases or symptoms of calcification