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Fahr's Disease

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Rachel Moyer

on 4 December 2013

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Transcript of Fahr's Disease

Normal Brain
Fahr's Patient Brain
By Rachel Moyer
Fahr's Disease
- seizures
- behavior issues/mood disorders
- motor and speech difficulty
- decreased cognition
- hallucinations and schizophrenia
like behavior

Symptoms
"normal" brain vs. Fahr Patient Brain
Calcification Inhibits:
- Glucose Uptake
- Blood Flow
Involves the
calcification
of the:

- basal ganglia
- cerebellum
- thalamus
- hippocampus
Causes:
-Genetic
- gene located on chromosome 14q
-Organic psychosis
- the presence of one neurological disease arises from another disease
- often found in conjunction with Parkinson's disease or schizophrenia
-Makes scientists wonder which came first
What does Fahr's Disease Tell Us about the Brain?
- since the calcification decreases functioning of affected
areas, it is often compared to a brain lesion (calcium
interferes with feedback loops)
- impaired motor function correlated with basal ganglia
- also explains schizophrenic symptoms
- tells us which regions rely on the calcified ones
(functioning in related regions will also decrease)

Bibliography

Albin, R. L., Young, A. B., & Penney, J. B. (1989). The functional anatomy of basal ganglia disorders. Trends in neurosciences, 12(10), 366-375.
Benke, T., Karner, E., Seppi, K., Delazer, M., Marksteiner, J., & Donnemiller, E. (2004). Subacute dementia and imaging correlates in a case of Fahr’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 75(8), 1163-1165.
Chiu, H. F., Lam, L. C., Shum, P. P., & Li, K. W. (1993). Idiopathic calcification of the basal
ganglia. Postgraduate medical journal, 69(807), 68-70.
Francis, A. F. (1979). Familial basal ganglia calcification and schizophreniform psychosis. The British Journal of Psychiatry.
Geschwind, D. H., Loginov, M., & Stern, J. M. (1999). Identification of a locus on chromosome
14q for idiopathic basal ganglia calcification (Fahr disease). The American Journal of Human Genetics, 65(3), 764-772.
Hempel, A., Henze, M., Berghoff, C., Garcia, N., Ody, R., & Schröder, J. (2001). PET findings and neuropsychological deficits in a case of Fahr's disease. Psychiatry Research: Neuroimaging, 108(2), 133-140.
Hoque, M. A., Siddiqui, M. R., Arafat, Y., Khan, S. U., Rahman, K. M., Mondol, B. A., &
Mohammad, Q. D. (2010). Fahr's disease: a very rare cause of epilepsy. Mymensingh medical journal: MMJ, 19(1), 127.
Malik, R., Pandya, V. K., & Naik, D. (2004). Fahr disease-a rare neurodegenerative disorder. Indian Journal of Radiology and Imaging, 14(4), 383.
Shouyama, M., Kitabata, Y., Kaku, T., & Shinosaki, K. (2005). Evaluation of regional cerebral
blood flow in Fahr disease with schizophrenia-like psychosis: a case report. American journal of neuroradiology, 26(10), 2527-2529.
Warren, J. D., Mummery, C. J., Al‐Din, A. S., Brown, P., & Wood, N. W. (2002). Corticobasal
degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look‐alike?. Movement disorders, 17(3), 563-567.
Wider, C., Dickson, D. W., Schweitzer, K. J., Broderick, D. F., & Wszolek, Z. K. (2009).
Familial idiopathic basal ganglia calcification: a challenging clinical–pathological correlation. Journal of neurology, 256(5), 839-842.
Treatment:
- no true cure, but scientists are researching the effects of
bisphosphonates
- treat underlying diseases or symptoms of calcification
Full transcript