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The Oncoproteins of Human Tumor Viruses

Conclusion

Epstein–Barr Virus

Ras

EBNA-3B

LMP-1 expression leads to activation of several signaling pathways ,NF-kB, Jak/Stat, MAP kinase, PI3K/Akt that lead to cytokine production and inhibition of apoptosis.

Cell Transformation

Human T lymphotrophic virus type 1 (HTLV-1)

B and T cell lymphomas, Hodgkin’s disease and Nasopharyngeal Carcinomas.

HTLV-1

What is the oncoprotein?

Oncoprotein: A protein encoded by an oncogene which can cause the transformation of a cell into a tumor cell.

Proto-oncogene

Example: Ras

Hepatitis C Viruses (HCV)

Hepatitis B virus (HBV)

Human Herpes virus-8 (HHV-8)

M.phil Student: Hu Chenghua

Core & NS4

……

NS4

The human herpes virus 8 is also known as Kaposi sarcoma(KS)-associated herpes virus (KSHV)

Hepatocellular Carcinoma (HCC)

Supervisor: Prof. Paul Chan

Human Papilloma virus (HPV)

Joint Graduate Seminar, 16th December 2014

Department of Microbiology

Faculty of Medicine

The Chinese University of Hong Kong

pRb

The p53 protein is crucial in human body, where it regulates the cell cycle and conserving stability by preventing genome mutation, functions as a tumor suppressor.

The retinoblastoma protein

Prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

Cervical, Anal, Penile, Vaginal, and Vulvar cancers

p53

Genital Mucosa

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