Module 3 Presentation

Module 3 Presentation

Literature Cited

Have you been paying attention?

Electron Transport Chain

Make your own electron transport chain!

Carolyn Nelson, Catherine Stephens, Arshiya Lal, Courtney Burton

Gubert, Carolina, Laura Stertz, Bianca Pfaffenseller, Bruna Schilling Panizzutti, Gislaine Tezza Rezin,

Raffael Massuda, Emilio Luiz Streck, Clarissa Severino Gama, Flávio Kapczinski, and Maurício Kunz. 2013.

Mitochondrial Activity and Oxidative Stress Markers in Peripheral Blood Mononuclear Cells of Patients with

Bipolar Disorder, Schizophrenia, and Healthy Subjects.Journal of Psychiatric Research. 47, no. 10: 1396.

Richardson, R. S., Duteil, S., Wary, C., Wray, D. W., Hoff, J. and Carlier, P. G. (2006), Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability. The Journal of Physiology, 571: 415–424. doi: 10.1113/jphysiol.2005.102327

Cellular Respiration. Cellular Respiration. Southwest

Kaiser, Gary. ATP Production. Chemiosmotic Phosphorylation

UCLA Researchers Map How Schizophrenia Engulfs Teen Brains. Schizophrenia.com. Brain Disease Process.

UCLA

Complexes: I, II, III, IV NADH NAD+ and H+ FADH2 FAD and 2H+ Co Enzyme Q Cytochrome C 6H+ ATP Synthase ADP+Pi ATP 2H+ (x3)

Why is the Electron Transport Chain important?

It's electric!

Electron Transport Chain in the Presence of Oxygen

(1/2) O2 + H2 ---> H2O

Study: Involvement of Mitochondrial Dysfunction in Schizophrenia

Study: Oxygen Transport: Air to Muscle Cells

http://www.zazzle.com/electron+stickers

ATP Production

Methods: Human knee-extensor studies focusing on determinants of maximal O2 consumption in exercising muscles.

Results: Under hypoxic conditions: A fall in arterial O2 saturation, calculated arterial P, and a subsequent elevation in heart rate.

Produces 32-34 ATP!

http://faculty.southwest.tn.edu/rburkett/GB%201%20cell%20resp.htm

• schizophrenic inviduals compared to healthy controls
• Findings
• decreased activity in complex I within brain tissues
• reduced ATP levels
• no differences in complex II or III

Red Blood Cells Use Anaerobic Respiration

http://betterknowbio.wordpress.com/2012/10/07/bio-105-ch-4/

But what about when oxygen is limited?

So why is oxygen important?

Anaerobic fermentation!

http://www.lovescott.com/tag/dominos/

Efficiency.

Larger, more complex life forms.

Importance in Cellular Respiration!

http://www.alpinehomemedical.com/oxygen

http://highergroundbrewery.com

http://www.ajs-destin.com/event_details.php?event_id=651

Richardson, R. S., Duteil, S., Wary, C., Wray, D. W., Hoff, J. and Carlier, P. G. (2006), Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability. The Journal of Physiology, 571: 415–424. doi: 10.1113/jphysiol.2005.102327

Keep up with energy demands.

Only 2 ATP produced!

http://slicedbreadmag.com

http://www.schizophrenia.com/research/schiz.brain.htm

http://vcell.ndsu.edu/animations/etc/first.htm

Energy Flow Through the Electron Transport Chain

http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit1/prostruct/fg5.html

Gubert, Carolina, Laura Stertz, Bianca Pfaffenseller, Bruna Schilling Panizzutti, Gislaine Tezza Rezin,

Raffael Massuda, Emilio Luiz Streck, Clarissa Severino Gama, Flávio Kapczinski, and Maurício Kunz. 2013. Mitochondrial Activity and Oxidative Stress Markers in Peripheral Blood Mononuclear Cells of Patients with Bipolar Disorder, Schizophrenia, and Healthy Subjects.Journal of Psychiatric Research. 47, no. 10: 1396.