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Osteogenesis Imperfecta is hereditary and is caused by a defect in the gene that produces collagen type 1, which is an essential building block of bone. There are many different defects that can affect this gene. The severity of OI depends on the specific gene defect. OI is an autosomal dominant disease. That means if you have one copy of the gene, you will have the disease. Most cases of OI are inherited from a parent, although some cases are the result of new genetic mutations. A person with OI has a 50% chance of passing on the gene and the disease to their children.
Osteogenesis Imperfecta (OI) is a hereditary disorder in the connective tissue that weakens bones, causing them to break easily. OI is a lethal form of “brittle bone disease” and varies from Type I to IV based on severity.
Because OI is a genetic condition, it has no cure. However, specific therapies can reduce the pain and complications associated with OI. Bisphosphonates are drugs that have been used to treat osteoporosis which can increase the strength and density of the bone, and also have been shown to greatly reduce bone pain and fracture rate. Low impact exercises, such as swimming, keep muscles strong and help maintain strong bones. In more severe cases, surgery to place metal rods into the long bones of the legs may be considered to strengthen the bone and reduce the risk of fracture. Bracing can also be helpful for some people. Reconstructive surgery may be needed to correct any deformities.
Any bone in the body can be affected, but long bones such as the tibia, fibula, femur, metatarsals, phalanges, humerus, ribs, etc. It's also common for the limbs to occasionally pop out of their sockets.
https://www.nlm.nih.gov/medlineplus/ency/article/001573.htm
https://www.genome.gov/25521839
http://www.nytimes.com/health/guides/disease/osteogenesis-imperfecta/overview.html
https://www.google.com/search?q=osteogenesis+imperfecta&espv=2&biw=1366&bih=623&site=webhp&source=lnms&tbm=isch&sa=X&ved=0CAYQ_AUoAWoVChMIzZD1_biqyAIVAe6ACh0DaAJa
It's important to know what "Brittle Bones Disease" is because it informs people the essential building blocks to strong bones in order to lead healthy lives.