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Inadequate viral suppression
Development of drug resistant strains
Ongoing viral replication
Deterioration of immune system
Clinical disease progression
Treatment failure
Death
>ART adherence is important in order to avoid the development of resistant strains of HIV and treatment failure.
>For viral suppression to be successful the body needs continuous supply of drugs.
Immune Reconstitution Inflammatory Syndrome (IRIS)
There is no single agreed upon definition for IRIS
There are 2 presentations
Paradoxical IRIS: worsening of symptoms of a known disease during ART
Unmasking IRIS: present of an occult opportunistic infection , in which disease that was not clinically apparent prior to ART, manifests during ART
How to take the drugs correctly
How not taking the drugs correctly leads to resistance and treatment failure
Strategies to help improve adherence: using reminders, involving a family member
Assess adherence to condom use
Poor counseling to treatment
Lack of family/community support
Side effects of drugs
Long term therapy
Stigma and discrimination
Health status of a patient
Financial status: examinations cost may hinder the client from receiving help)
Distance to the health facility
Missing appointments
Taking the correct number of doses at the correct time in the correct way for as long as prescribed is called adherence to treatment.
The client should at least take 95% of the doses to suppress the virus.
The client should be able to Keep all clinic appointments and other instructions given by clinic staff is called adherence to care.
By the end of this session the participants should be able to:
Define adherence
Describe the importance of adherence in successful antiretroviral Therapy
Drugs Resistance
IRIS