Introducing
Your new presentation assistant.
Refine, enhance, and tailor your content, source relevant images, and edit visuals quicker than ever before.
Trending searches
The chief constituent of calabar bean the physostigmine (eserine) ,which is the medicinally ,useful alkaloid. it also contains starch and protine ,in addition , the calabar bean contains small quantities of a number of other alkaloide which include: geneserine ,eseramin ,iso - physostigmine , physovenine , nor- physostigmine, and small amount of fixed oil.
1- physostigmaine is used to treat glucoma because it crosses the BBB .
2-treatment of tetanus as a antidote
3- miotic effecte
4- Epilepsy
5- Cholera
its extremely toxic
Excessive saliva and sweating
Reduced eye pupil size
Vomiting , diarrhea , coma
blood pressure change , coma
Bradycardia, sever muscle weakness
Respiratory depression
cholinergic crisis
physostigmaine inhibits acetylcholinesterase , the enzyme responsible for the breakdown of used acetylcholine . By interfering with the metabolism of acetylcholine , physostigmine indirectly stimulates both nicotinic and muscarinic receptor due to the consequential increase of acetylcholine at the synaptic cleft .
- You are pregnant or breast-feeding
- You have parkinson's disease
- You have heart disease or slow heartbeat
- You have asthma
- You have diabetes
- You have poor blood circulation leading to tissue death ( gangrene )
- You have blockage of the intestinal tract
https://thepharmacognosy.com/calabar-beans/
https://reference.medscap.com/drug/physotigmine-343743