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Metabotopic vs Ionotropic
Overview Of Ionotropic receptors
Ionotropic receptors are associated with ligand gated ion channels.
When the ligand binds to the receptor, the channel changes conformation, enabling ions to flood in.
Ionotropic receptors have a quicker response time than metabotropic, as they are directly linked to the i...
Ionotropic receptors have a quicker response time than metabotropic, as they are directly linked to the ion channel.
Overview of Metabotropic receptors
Metabotropic
Metabotropic receptors are also associated with ion channels, yet less directly as they instead activate G-proteins, causing second messenger cascades, which could ultimately lead to the opening of an ion channel, or have completely different effects.
GPCR's (G-protein coupled receptors) are trimeric, meaning they have 3 subunits, and they span t...
GPCR's (G-protein coupled receptors) are trimeric, meaning they have 3 subunits, and they span the plasma membrane 7 times
Structure of an Ionotropic receptor
Structure of an ionotropic receptor
Structure of a GPCR
Structure of a GPCR
Examples of ionotropic
Glycine(Only one that is soley ionotropic)
GABA
GLUTAMATE
SEROTONIN
ATP
ACETYLCHOLINE
Examples of metabotropic
GABA
Glutamate
Dopamine
Norepinephrine
Epinephrine
Serotonin
Histamine
Adenosine
ATP
Acetylcholine
References
Khan Academy. (2018). Neurotransmitters and receptors. [online] Available at: https://www.khanacademy.org/science/biology/human-biology/neuron-nervous-system/a/neurotransmitters-their-receptors [Accessed 9 Feb. 2018].
Purves, D., Augustine, G., Fitzpatrick, D., Katz, L., LaMantia, A., McNamara, J. and Williams, S. (2001). Two Families of Postsynaptic Receptors. [online] Ncbi.nlm.nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK10855/ [Accessed 9 Feb. 2018].
Bristol.ac.uk. (2017). Glutamate receptors Centre for Synaptic Plasticity University of Bristol. [online] Available at: http://www.bristol.ac.uk/synaptic/receptors/ [Accessed 9 Feb. 2018].