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Receptor Classifications (Ionotropic and metabotropic)

Metabotopic vs Ionotropic

By Eugenia Davidson

Overview Of Ionotropic receptors

Ionotropic

Ionotropic receptors are associated with ligand gated ion channels.

When the ligand binds to the receptor, the channel changes conformation, enabling ions to flood in.

Ionotropic receptors have a quicker response time than metabotropic, as they are directly linked to the i...

Ionotropic receptors have a quicker response time than metabotropic, as they are directly linked to the ion channel.

Overview of Metabotropic receptors

Metabotropic

Metabotropic receptors are also associated with ion channels, yet less directly as they instead activate G-proteins, causing second messenger cascades, which could ultimately lead to the opening of an ion channel, or have completely different effects.

GPCR's (G-protein coupled receptors) are trimeric, meaning they have 3 subunits, and they span t...

GPCR's (G-protein coupled receptors) are trimeric, meaning they have 3 subunits, and they span the plasma membrane 7 times

They are called G-protiens because they bind to either GDP or GTP

Structure of an Ionotropic receptor

Structure of an ionotropic receptor

Structure of a GPCR

Structure of a GPCR

Examples of ionotropic

Glycine(Only one that is soley ionotropic)

GABA

GLUTAMATE

SEROTONIN

ATP

ACETYLCHOLINE

Examples of metabotropic

GABA

Glutamate

Dopamine

Norepinephrine

Epinephrine

Serotonin

Histamine

Adenosine

ATP

Acetylcholine

References

References

Khan Academy. (2018). Neurotransmitters and receptors. [online] Available at: https://www.khanacademy.org/science/biology/human-biology/neuron-nervous-system/a/neurotransmitters-their-receptors [Accessed 9 Feb. 2018].

Purves, D., Augustine, G., Fitzpatrick, D., Katz, L., LaMantia, A., McNamara, J. and Williams, S. (2001). Two Families of Postsynaptic Receptors. [online] Ncbi.nlm.nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK10855/ [Accessed 9 Feb. 2018].

Bristol.ac.uk. (2017). Glutamate receptors Centre for Synaptic Plasticity University of Bristol. [online] Available at: http://www.bristol.ac.uk/synaptic/receptors/ [Accessed 9 Feb. 2018].

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