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Cancer Treatment & Discovery Timeline

By: Lien Nguyen

1846

The first used of anesthesia in surgery

1846

  • On October 16, William T. G. Morton made history by being first in the world to publicly and successfully demonstrate the use of ether anesthesia for surgery.
  • Advance gain immediate and widespread attention. Making the modern era of surgery.

1895

X-ray

A german professor, Wilhelm Conrad Rontgen, discovered X-ray.

1895

1898

Radium & Polonium

1898

  • Marie and Pierre Curie discover the radioactive elements radium and polonium.
  • Later the use of radium in cancer treatment begins (effectively treat tumors).

1900- 1950

Radiotherapy

1900-1950

  • Radiotherapy was developed as a treatment for cancer
  • It's the use of radiation to kill cancer cells or stop them dividing
  • It exploded in the U.S.
  • The extensive side effects of radium surfaced among worker, include acute and long- term.

1949

Discovery of Chemotherapy

1949

  • Chemotherapy for Hodgkin lymphoma
  • Nitrogen mustard kills cancer cells by modifying the DNA through a process called alkylation
  • Advancement in chemotherapy and the drug still receives some use today with chemotherapy

1971

Radioimmunoassay Created

1971

  • A radioimmunoassay made to detect alpha-fetoprotein, a tumor marker often found in higher concentrations in those with liver and testicular cancer
  • created for screening purposes by Ruoslahti and Seppala

1979

p53

  • p53 is discovered
  • the most commonly mutated gene in human cancer
  • It is a tumor suppressor gene

1979

1981

Hepatitis B vaccine

1981

  • FDA approves the first vaccine against hepatitis B
  • Hepatitis B is one of the primary causes of liver cancer

1990

Laparoscopic Surgery

1990

  • Laparoscopic surgery allow patients to recover faster and experience less pain without sacrificing effectiveness
  • It a surgery that make several small incision and use telescoping equipment to remove tumor

1998

Trastuzumab

1998

  • FDA approves trastuzumab for the treatment of women with HER2-positive metastatic breast cancer
  • Later approved for the adjuvant (post-operative) treatment of women with HER2-positive early-stage breast cancer

2017

First gene therapy for cancer

2017

  • CAR-T therapy works by genetically modifying the patient’s own immune T cells to target a specific cancer protein and ultimately trigger the cancer cell’s destruction.
  • CAR T cells continue to multiply in the patient’s body, so the anticancer effects of CAR T cells persist and can even increase over time.
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