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Primary
- chancre - firm, round and painless
Secondary
- Sores in mouth, vagina or anus. Rash (red, rough and spotted)
Latent
- No symptoms
Tertiary (10-30 years)
- Fatal
- Affect multiple organ systems
Early in fetal period (14-16 weeks)
Pass through layers of amniotic sac
Vertical tranmission - durning birth
VDL/RPR
Penicillin G
Desensitization to Penicillin