Introducing
Your new presentation assistant.
Refine, enhance, and tailor your content, source relevant images, and edit visuals quicker than ever before.
Trending searches
Theories of Primary Aging
21
Theories of Primary Aging
Presented by Brad, Breanna, Mitchell, and Morgan
Primary Aging
Introduction
Consits of the gradual, inevitable changes that will happen to most of us as we go through adulthood.
Download the app Kahoot or access on your laptop
Oxidative Damage
Oxidative Damage
One of several factors involved in human aging.
Theorists: Denham Harmon, Debra Heller, Gerald McClearn
Free Radicals
Molecules/atoms with an unpaired electron.
Molecules enter into many potentially damaging chemical reactions, most of which a healthy body can resist or repair.
Restitant and repair functions decline as we age.
Results in primary aging.
Free Radicals
Antioxidants
Antioxidants
Substances with properties that protect against oxidative damage.
No evidence they delay primary aging or extend life span.
APOPTOSIS:
Bonus
Meaning the natural death of cells.
Genetic Limits:
Genetic Limits
Every species has a maximum age limit
Example:
Humans max age = 110, Galapagos giant tortoise max age = 190
Theorists: Leonard Hayflick, Tim D. Spector
Hayflick Limit:
Maximum number of times cells are programmed to divide for a species.
Hayflick Limit
Replicative Senescence:
Replicative Senescence
State in which older cells stop dividing.
Telomeres:
Telomeres
Lengths of repeating DNA that chromosomes have at their tips.
Men and Women are born with the same length telomeres.
Telomere length has been related to both primary and secondary aging.
Theorist Focus:
Theorist
Medical researcher Tim D. Spector and his colleagues (Cherkas, Hunkin, Kato, et al., 2008) focused on loss of telomere length in their study.
Caloric Restrictions:
Caloric Restriction
Aging affects diet.
Aging affects diet
Aging affects diet
How...
Early Studies...
Recent Studies...
Caloric Restrictions in Humans:
CR in Humans
Caloric Intake...
Studies and Effects....
Further Research:
Further Research
Resveratrol...
Rapamycin...
TOR...
1:30 - 3:00
Bonus
Theorists
- Herman
- Coelho
- Kapahi
- Kockel
- Miller
- Harrison
- Astle
- Strong
- Sharp
- Holloszy
- Polivy
Theorists
- Hornsby
- Aviv
- Epel
- Blackburn
- Lin
- Tim D. Spector
- Cherkas
- Hunkin
- Kato
- McCay
- Crowell
- Maynard
-Colman
- Anderson
- Johnson
- Finch
- Austad
- Gerald McClearn
- Debra Heller
- Denham Harmon
- Bengston
- Gans
- Putney
- Lustgarten
- Muller
- Van Remmen
- Leonard Hayflick
- Fontana
McClearn Contributions
McClearn
McClearn and Heller suggested:
“the scientific pessimist might lament the absence of a compelling unified theory, the scientific optimist will revel in the richness of the empirical data and the diversity of the current theoretical propositions.” (McClearn, Heller, 2000).
Argued for the reliability, validity, and generalizability of “biomarkers”
argued that our understanding of aging will evolve from the application of a diverse set of biomarker variables.
Heller Contributions
Heller
Was the first identified by heller in 1956 that primary aging is based on random damage that takes place at the cellular level.
Involves the release of “free radicals”, molecules and atoms.
Harmon Contributions:
Harmon
Father of the free radical theory of aging.
Published a hypothesis entitled “Is the Mitochondrion the True Biological Clock?”.
Purposed Mitochondrion is the true biological clock.
Hayflick Contributions:
Hayflick
Proposed that there is a genetic program setting the upper age limit of each species (1977, 1994).
Spector Contributions:
Spector
Examined the potential role of telomere length in human longevity in two settings: contemporary life expectancy, and life expectancy of 100 years.
Focused on loss of telomere length.
References:
Sources
1)
rider168PH. “Primary and Secondary Aging.” YouTube, YouTube, 21 Jan. 2014, www.youtube.com/watch?v=vZVx7MlkTTc.
2)
Bjorklund, Barbara R. The Journey of Adulthood. Pearson, 2016.
Critical Thinking
https://play.kahoot.it/#/k/cd7233d5-565a-492b-bf2b-8c3b6bde5047