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Osteoporosis
Osteoporosis is a systemic skeletal disorder that is characterized by the loss of bone tissue, disruption of bone architecture, and bone fragility, leading to an increased risk of fractures. T-score < -2.5
Osteopenia
... and osteopenia
T-score between -1.5 and -2.5.
33 million patinents in the US with osteopenia vs. 10 million with osteoporosis.
Postmenopausal osteoporosis
major cause of osteoporosis.
40% lifetime risk for postmenopausal women.
Postmenopausal
mechanism of path.
machanism
Low estrogen. Increased secretion of RANKL from osteoblasts. Proliferation and differentiation of osteoclasts.
+ age dependent mechanisms.
Disruption of trabecular connectivity
incompletely filled pits.
Osteoporotic fractures
Fractures
Hip-fractures
50% get permanent impaired mobility.
25% lose ability to live independently.
5-8 times higher morbidity for 3 months.
Hip
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