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EMS Sepsis Update

Eric Reid MD

Objectives

Overview

1. Review pathophysiology and epidemiology of sepsis

2. Discuss methods of identifying sepsis

3.Investigate future opportunities in sepsis care

Why We Care...

About 1.7 million/yr or 6% of admissions

270,000 deaths or ~15% mortality

40%-50% mortality if it progresses to shock

Most expensive condition in American Healthcare - >$24 Billion

By the Numbers

What It Is...

What It Is

Sepsis

Organ dysfunction caused by disregulated host response to an infection

Septic Shock

Circulatory and cellular/metabolic dysfunction associated with higher risk of mortality

Cellular Pathway

Pathway

Endotoxins/LPS

Macrophage Activation

TNF/IL/Interferon

Fever/Tachy NO/Vasodilation

Cellular Hypoxia

What It Isn't

Sepsis

Takeaways

Take Home

Requires Infection AND Inflammation

Doesn't require "Bad" infection

Organ dysfunction is host mediated

Case 1

Case 2

Case 3

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