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Abscesses

Abscesses are effectively enclosed cavities filled with Pus

Causes, Presentation, mechanisms

- Danny had a subdural abscess

- Generally caused by colonization of pyogenic bacteria following puncturing injury

-Infection with pyogenic bacteria often cause the creation of pus and fibrin which creats the wall

Common Pyogenic Bacteria:

Case Summary:

Danny an 18-year-old university student presents to GP, with moderately severe acne & abscess on left cheek. Abscess is drained and heals quickly. Swab of abscess tests positive for S. Aureus.

Acne

Bacteria enters into dermal layer & detected by Langerhans cells

Inflamatory response - recruitment of immune cells (i.e. PMNs)

Out out Damn'd Spot

Penetration: Commensal bacteria (S.aureus)

enters through the epidermis into the dermal

layers. Langerhans cells detect microbes →

inflammatory response → PMN’s/macrophages

- Pus Formation: Necrotic PMNs, dead bacteria

and cell debris build up

- Capsule Formation: Fibrinogen comes and

builds a fibrin mesh around the phagocytes →

forms a pseudo-capsule around site of

infection, trapping the necrotic tissue and pus

→ neutrophils can still infiltrate

- Maturation: Abscess continues to grow and

fibrinous membrane becomes impenetrable

and body cannot dispose of the exudate → no

entry/exit of cells → oedema and redness

surrounding the area – requires lancing

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