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Abscesses
Abscesses are effectively enclosed cavities filled with Pus
Causes, Presentation, mechanisms
- Danny had a subdural abscess
- Generally caused by colonization of pyogenic bacteria following puncturing injury
-Infection with pyogenic bacteria often cause the creation of pus and fibrin which creats the wall
Common Pyogenic Bacteria:
Case Summary:
Danny an 18-year-old university student presents to GP, with moderately severe acne & abscess on left cheek. Abscess is drained and heals quickly. Swab of abscess tests positive for S. Aureus.
Acne
Bacteria enters into dermal layer & detected by Langerhans cells
Inflamatory response - recruitment of immune cells (i.e. PMNs)
Out out Damn'd Spot
Penetration: Commensal bacteria (S.aureus)
enters through the epidermis into the dermal
layers. Langerhans cells detect microbes →
inflammatory response → PMN’s/macrophages
- Pus Formation: Necrotic PMNs, dead bacteria
and cell debris build up
- Capsule Formation: Fibrinogen comes and
builds a fibrin mesh around the phagocytes →
forms a pseudo-capsule around site of
infection, trapping the necrotic tissue and pus
→ neutrophils can still infiltrate
- Maturation: Abscess continues to grow and
fibrinous membrane becomes impenetrable
and body cannot dispose of the exudate → no
entry/exit of cells → oedema and redness
surrounding the area – requires lancing