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SAAD SBAA
Pr. M. Faroudy
1962
taken off the market
1995
came back as an orphan drug
present day
5α-reductase
Dihydrotestosterone
Testosterone
testosterone
(AAR = 1:1)
oxandrolone
(AAR = 630:24)
AAS
Extracellular
fluid
Plasma
membrane
Intracellular
receptor
Cytoplasm
DNA
Nucleus
Protein
synthesis
+
Blocks Cortisol effect on LBM
This medication is used to offset Protein Catabolism and help patients regain weight lost due to various conditions.
Side effects are linked to the androgenic nature of the drug.
At high doses, patients may experience symptoms of masculinization such as acne, increased hair growth, voice changes, increased sexual desire,...
Uniquely amongst AAS that are active by mouth, Oxandrolone seem to have little risk of liver toxicity.
Oxandrolone does not generally cause gynecomastia, as it does not aromatize into estrogenic metabolites.