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Ototoxic Drugs

Group B3

Supervisors:

Dr. Fatma Eldosoky

Dr. Azza Taha

Objectives:

Objectives

  • List clinically important classes of ototoxic drugs
  • Give examples of individual drugs that cause ototoxicity.
  • Explain the mechanism of ototoxic adverse effect of some drugs
  • Identify the risk factors which potentiate ototoxicity of the drugs.
  • List precautions which should be observed in high risk and pregnant patients when they receive ototoxic drugs .

Case Senaeio

CC: A 55 years old patient, known case of HF and IHD, presented to ED complaining of hearing loss for 2 days.

 

HPI: hearing loss is bilateral, started gradually, progressive with no aggravating or relieving factors and associated with vertigo. Patient denied pain, fever, or trauma to his head or ear. 

Past Hx: Patient has Hx of IHD, HF, and he was just diagnosed with malaria since he came back from Jazan 2 months ago. He was also diagnosed with testicular tumor. Patient denied any major or minor surgical procedures.

Medications: Aspirin, furosemide, quinin, cisplastin.

Allergy: NKA

Family Hx: His father was diagnosed with reversable drug induced hearing loss after the use of vancomycin and gentamycin.

Social Hx: Patient is working in his farm,

and he is a smoker for 25 years.

Definition

Definetion of Ototoxic Drugs:

a drug or chemical related damage to the inner ear , resulting damage to organs responsible for hearing and balance. The damage can lead to temporary or permanent hearing loss and / or loss of balance .

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