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Under-supervision of:
Dr.Hisham Alrefai
Proper-by
1-Introduction
2-Objectives
3-materials and method
4-Expiremental Design
5-Time frame of our process
Background..
Breast cancer (BC) is a devastating and most common life-threatening cancer in women responsible for about 20 percent of cancer mortality in population. There are four main major breast cancer subtypes have been identified based on the estrogen receptor (ER), progesterone receptor (PR), and HER2. Triple-negative breast cancer (TNBC).
1-Research questions
2-Aim of the work
3-materials
2-Doxorubicin
1-Tamoxifen
3-Liposomes
4-MTT solution
5-MCF-7 estrogen sensitive
6-MDA-MB-231 estrogen negative
method..
Expiremental Design
in-vitro study
Group1 control group of non-treated cell lines ( MCF-7 est/S) and (MDA-MB-231 est/N)
Group 2 Treatment of both cell lines with
doxorubicin alone
Group 3 Treatment of both cell lines with
doxorubicin/tamoxifen combination
Group 4 Treatment of both cell lines with
doxorubicin/tamoxifen combination in the
delivery formula