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In 1945 the Joint Intelligence Objectives Agency was established and given direct responsibility for Operation Paperclip which recruited former Nazi scientists specialising in aerodynamics and rocketry, chemical weapons, chemical reaction, technology and medicine to work for the CIA. Several secret U.S. government projects stemed out of Operation Paperclip including Project Bluebird which was renamed Project Artichoke in 1951. This project was headed by the CIA´s Office of Scientific Intelligence.
The question they wanted to answer was "Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature, such as self-preservation?"
Project Artichoke developed mind control techniques and experimented in inducing amnesia and highly suggestive states in its subjects. The project focused on the use of hypnosis, forced morphine addiction and withdrawal, along with other drugs, chemicals, and techniques.
The operation began in the early 1950s and was officially permitted to become a project in 1953, but their funding was reduced in 1964, then further reduced in 1967, and officially shut down in 1973.
Given the CIA's purposeful destruction of most records, its failure to follow informed consent protocols with thousands of participants, the uncontrolled nature of the experiments, and the lack of follow-up data, the full impact of Project Artichoke experiments, including deaths, will most likely never be known.
Although the CIA released the recovered notes and memos on the experiments they conducted, the documents are severely edited and don´t reveal much on what they did during the years they preformed the project.
No, it was not ethical due to the fact that they attempted to use drugs as a form to control someone. Mind control is not ethical in it self because if you´re taking away someone´s basic right to think, that´s not right because then that person is no longer who they are.
Although most of the test subjects were unwilling to participate, there were several volunteers such as :
Ken Kesey, author of One Flew Over the Cuckoo's Nest, volunteered for the experiments involving LSD and other psychedelic drugs while he was a student at Stanford University.
Stanford University test subjects were paid to take LSD, psilocybin, and mescaline, then report on their experiences.
Leader of the Winter Hill Gang in Boston James Bulger volunteered for testing while in prison in Atlanta in 1957.
externalfile:drive-533580cc7567cf290be30a9786be810057acd129/root/Project Artichoke Manchurian candidate CIA.pdf
https://sleepbutawhile.com/2011/03/01/inconvenient-truth-9-project-artichoke-the-manchurian-candidate/
https://www.youtube.com/watch?v=-gvDih2moIs